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Sepsis in Children: Global Implications of the World Health Assembly Resolution on Sepsis

Kissoon, Niranjan MD, FRCPC, CPE, FAAP, MCCM, FACPE1; Reinhart, Konrad MD, ML2; Daniels, Ron MBChB, FFICM, FRCA, FRCPEd3; Machado, Machado Flavia R. MD, PhD4; Schachter, Raymond D. BSc, LLB5; Finfer, Simon FCICM, DrMed6

doi: 10.1097/PCC.0000000000001340
Online PCCM Perspectives

Background: Sepsis, worldwide the leading cause of death in children, has now been recognized as the global health emergency it is. On May 26, 2017, the World Health Assembly, the decision-making body of the World Health Organization, adopted a resolution proposed by the Global Sepsis Alliance to improve the prevention, diagnosis, and management of sepsis.

Objective: To discuss the implications of this resolution for children worldwide.

Conclusions: The resolution highlights sepsis as a global threat and urges the 194 United Nations member states to take specific actions and implement appropriate measures to reduce its human and health economic burden. The resolution is a major step toward achieving the targets outlined by the Sustainable Developmental Goals for decreasing mortality in infants and children, but implementing it will require a concerted global effort.

Supplemental Digital Content is available in the text.

1Department of Pediatrics, Division of Critical Care, BC Children’s Hospital and CFRI, University of British Columbia, Vancouver, BC, Canada.

2Department of Anesthesiology and Intensive Care Medicine, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany.

3Department of Critical Care, Heart of England NHS Foundation Trust, England, United Kingdom.

4Department of Anesthesiology, Pain and Intensive Care, Federal University of Sao Paulo and Sepsis Institute, Latin America.

5Global Sepsis Alliance (GSA) and Synergy Business Lawyers, Vancouver, BC, Canada.

6Department of Critical Care Medicine, The George Institute for Global Health, University of New South Wales, Sydney, NSW, Australia.

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Dr. Kissoon has disclosed that all authors are members of the Global Sepsis Alliance Executive Committee. Dr. Reinhart received funding from Adrenomed Berlin/Henningsdorf (consulting) and InflaRx, a spin off of Jena University Hospital (equity), and he disclosed that he is an unpaid chair of the Global Sepsis Alliance, which received sponsorship by Thermofisher, Commonwealth Serum Laboratories (CLS) Behring, Becton Dickinson, and some other companies. Dr. Finfer’s institution received funding from Baxter Healthcare and CSL. The remaining authors have disclosed that they do not have any potential conflicts of interest.

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©2017The Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies