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Adverse Tracheal Intubation-Associated Events in Pediatric Patients at Nonspecialist Centers: A Multicenter Prospective Observational Study*

Matettore, Adela MD, FRCPC, FAAP1,2; Ramnarayan, Padmanabhan FRCPCH, FFICM1,3; Jones, Andrew MBBS, MRCPCH, MSc1,2; Randle, Elise MBBS, MRCPCH1,2; Lutman, Daniel MBBS, FRCA, FFICM1,4; O’Connor, Maeve MB BAO, FCAI1,5; Chigaru, Linda MBChB, FRCA1,6

Pediatric Critical Care Medicine: June 2019 - Volume 20 - Issue 6 - p 518-526
doi: 10.1097/PCC.0000000000001923
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Objectives: In tertiary care PICUs, adverse tracheal intubation-associated events occur frequently (20%; severe tracheal intubation-associated events in 3–6.5%). However, pediatric patients often present to nonspecialist centers and require intubation by local teams. The rate of tracheal intubation-associated events is not well studied in this setting. We hypothesized that the rate of tracheal intubation-associated events would be higher in nonspecialist centers.

Design: Prospective observational study.

Setting: We conducted a multicenter study covering 47 local hospitals in the North Thames and East Anglia region of the United Kingdom.

Patients: All intubated children transported by the Children’s Acute Transport Service from June 2016 to May 2018.

Interventions: None.

Measurements and Main Results: Data were available in 1,051 of 1,237 eligible patients (85%). The overall rate of tracheal intubation-associated events was 22.7%, with severe tracheal intubation-associated events occurring in 13.8%. Younger, small-for-age patients and those with difficult airways had a higher rate of complications. Children with comorbidities and difficult airways were found to have increased severe tracheal intubation-associated events. The most common tracheal intubation-associated events were endobronchial intubation (6.2%), hypotension (5.4%), and bradycardia (4.2%). In multivariate analysis, independent predictors of tracheal intubation-associated events were number of intubation attempts (odds ratio for > 4 attempts compared with a single attempt 19.1; 95% CI, 5.9–61.4) and the specialty of the intubator (emergency medicine compared with anesthesiologists odds ratio 6.9; 95% CI, 1.1–41.4).

Conclusions: Tracheal intubation-associated events are common in critically ill pediatric patients who present to nonspecialist centers. The rate of severe tracheal intubation-associated events is much higher in these centers as compared with the PICU setting. There should be a greater focus on improving the safety of intubations occurring in nonspecialist centers.

1Children’s Acute Transport Service, Boswell Street, Great Ormond Street Hospital, London, United Kingdom.

2Paediatric Intensive Care Unit, Great Ormond Street Hospital, Great Ormond Street, London, United Kingdom.

3Paediatric Intensive Care Unit, St. Mary’s Hospital, Praed Street, London, United Kingdom.

4Department of Anaesthesia, Royal London Hospital, Whitechapel Road, London, United Kingdom.

5Paediatric Intensive Care Unit, Evelina London Children’s Hospital, St Thomas’ Hospital, Westminster Bridge Road, London, United Kingdom.

6Department of Anaesthesia, Great Ormond Street Hospital, Great Ormond Street, London, United Kingdom.

*See also p. 572.

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The authors have disclosed that they do not have any potential conflicts of interest.

For information regarding this article, E-mail: Adela.matettore@gmail.com

Copyright © 2019 by the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies