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Pathophysiology of the Gut and the Microbiome in the Host Response

Lyons, John D. MD; Coopersmith, Craig M. MD, FCCM

doi: 10.1097/PCC.0000000000001046
MODS Supplement

Objective: To describe and summarize the data supporting the gut as the motor driving critical illness and multiple organ dysfunction syndrome presented at the National Institute of Child Health and Human Development MODS Workshop (March 26–27, 2015).

Data Sources: Summary of workshop keynote presentation.

Study Selection: Not applicable.

Data Extraction: Presented by an expert in the field, the data assessing the role of gastrointestinal dysfunction driving critical illness were described with a focus on identifying knowledge gaps and research priorities.

Data Synthesis: Summary of presentation and discussion supported and supplemented by relevant literature.

Conclusions: The understanding of gut dysfunction in critical illness has evolved greatly over time, and the gut is now often considered as the “motor” of critical illness. The association of the gut with critical illness is supported by both animal models and clinical studies. Initially, the association between gut dysfunction and critical illness focused primarily on bacterial translocation into the bloodstream. However, that work has evolved to include other gut-derived products causing distant injury via other routes (e.g., lymphatics). Additionally, alterations in the gut epithelium may be associated with critical illness and influence outcomes. Gut epithelial apoptosis, intestinal hyperpermeability, and perturbations in the intestinal mucus layer have all been associated with critical illness. Finally, there is growing evidence that the intestinal microbiome plays a crucial role in mediating pathology in critical illness. Further research is needed to better understand the role of each of these mechanisms and their contribution to multiple organ dysfunction syndrome in children.

Both authors: Department of Surgery and Emory Critical Care Center, Emory University School of Medicine, Atlanta, GA.

This information or content and conclusions are those of the authors and should not be construed as the official position or policy of, nor should any endorsements be inferred by, the National Institutes of Health, the U.S. Department of Health and Human Services, or the U.S. government.

Supported, in part, by funding from the National Institutes of Health (GM072808, GM095442, GM104323, GM109779, GM113228, and GM117895).

Dr. Coopersmith’s institution received funding from the National Institutes of Health (NIH) and Society of Critical Care Medicine. He received grant support from the NIH. He disclosed that he was the president of Society of Critical Care Medicine in 2015. A stipend was paid to Emory University for his time in this role for part of 2014 (as president-elect) and in 2015 (as president). Drs. Coopersmith and Lyons received support for article research from the NIH.

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©2017The Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies