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Sepsis in Pediatric Cardiac Intensive Care

Wheeler, Derek S. MD, MMM; Wong, Hector R. MD

Pediatric Critical Care Medicine: August 2016 - Volume 17 - Issue 8 - p S266-S271
doi: 10.1097/PCC.0000000000000796
Organ Systems: Other Organ Systems and Systemic Disorders

Objectives: In this review, we will discuss risk factors for developing sepsis; the role of biomarkers in establishing an early diagnosis, in monitoring therapeutic efficacy, in stratification, and for the identification of sepsis endotypes; and the pathophysiology and management of severe sepsis and septic shock, with an emphasis on the impact of sepsis on cardiovascular function.

Data Source: MEDLINE and PubMed.

Conclusions: There is a lot of excitement in the field of sepsis research today. Scientific advances in the diagnosis and clinical staging of sepsis, as well as a personalized approach to the treatment of sepsis, offer tremendous promise for the future. However, at the same time, it is also evident that sepsis mortality has not improved enough, even with progress in our understanding of the molecular pathophysiology of sepsis.

Both authors: Department of Pediatrics, Section of Critical Care Medicine, Cincinnati College of Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH.

Supported, in part, by AHRQ R18 HS020455, National Institutes of Health RO1 GM099773, RO1 GM096994, and R01 GM108025.

Dr. Wheeler served as board member (he is Editor-in-Chief for the journal Current Treatment Options in Pediatrics [Springer]). Dr. Wong received support for article research from the National Institutes of Health (NIH). His institution received funding from the NIH.

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Copyright © 2016 by the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies