Institutional members access full text with Ovid®

Share this article on:

Children with single-ventricle physiology do not benefit from higher hemoglobin levels post cavopulmonary connection: Results of a prospective, randomized, controlled trial of a restrictive versus liberal red-cell transfusion strategy*

Cholette, Jill M. MD; Rubenstein, Jeffrey S. MD, MBA; Alfieris, George M. MD; Powers, Karen S. MD; Eaton, Michael MD; Lerner, Norma B. MD, MPH

Pediatric Critical Care Medicine: January 2011 - Volume 12 - Issue 1 - p 39-45
doi: 10.1097/PCC.0b013e3181e329db
Cardiac Intensive Care

Objective: To examine the impact of a restrictive vs. liberal transfusion strategy on arterial lactate and oxygen content differences in children with single-ventricle physiology post cavopulmonary connection. Children with single-ventricle physiology are routinely transfused postoperatively to increase systemic oxygen delivery, and transfusion thresholds in this population have not been studied.

Design: Prospective, randomized, controlled, clinical trial.

Setting: Pediatric cardiac intensive care unit in a teaching hospital.

Patients: Infants and children (n = 60) with variations of single-ventricle physiology presenting for cavopulmonary connection.

Interventions: Subjects were randomized to a restrictive (hemoglobin of <9.0 g/dL), or liberal (hemoglobin of ≥13.0 g/dL) transfusion strategy for 48 hrs post operation. Primary outcome measures were mean and peak arterial lactate. Secondary end points were arteriovenous (C(a-v)o2) and arteriocerebral oxygen content (C(a-c)o2) differences and clinical outcomes.

Measurements and Main Results: A total of 30 children were in each group. There were no significant preoperative differences. Mean hemoglobin in the restrictive and liberal groups were 11 ± 1.3 g/dL and 13.9 ± 0.5 g/dL, respectively (p < .01). No differences in mean (1.4 ± 0.5 mmol/L [Restrictive] vs. 1.4 ± 0.4 mmol/L [Liberal]) or peak (3.1 ± 1.5 mmol/L [Restrictive] vs. 3.2 ± 1.3 mmol/L [Liberal]) lactate between groups were found. Mean number of red blood cell transfusions were 0.43 ± 0.6 and 2.1 ± 1.2 (p < .01), and donor exposure was 1.2 ± 0.7 and 2.4 ± 1.1 to (p < .01), for each group, respectively. No differences were found in C(a-v)o2, C(a-c)o2, or clinical outcome measures.

Conclusion: Children with single-ventricle physiology do not benefit from a liberal transfusion strategy after cavopulmonary connection. A restrictive red blood cell transfusion strategy decreases the number of transfusions, donor exposures, and potential risks in these children. Larger studies with clinical outcome measures are needed to determine the transfusion threshold for children post cardiac repair or palliation for congenital heart disease.

From the Departments of Pediatrics (JMC, JSR, KSP, NBL), Cardiac Surgery (GMA), and Anesthesia (ME), Golisano Children's Hospital at Strong, University of Rochester Medical Center, Rochester, NY.

This study was supported, in part, by a University of Rochester Strong Children's Research Center Research Development Award, 2006-2007 (JMC).

The authors have not disclosed any potential conflicts of interest.

For information regarding this article, E-mail:

©2011The Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies