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Ventilator-associated pneumonia in intubated children: Comparison of different diagnostic methods*

Gauvin, France MD, MSc; Dassa, Clément PhD; Chaïbou, Mahamadou MD, MSc; Proulx, François MD; Farrell, Catherine Ann MD; Lacroix, Jacques MD

Pediatric Critical Care Medicine: October 2003 - Volume 4 - Issue 4 - p 437-443
doi: 10.1097/01.PCC.0000090290.53959.F4
FEATURE ARTICLES—CONTINUING MEDICAL EDUCATION
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Objectives To compare different methods for diagnosis of ventilator-associated pneumonia in intubated children.

Design Prospective epidemiologic study.

Setting Pediatric intensive care unit of a tertiary care university hospital.

Patients All consecutive pediatric intensive care unit patients <18 yrs of age with suspected ventilator-associated pneumonia.

Interventions For all patients, the following diagnostic methods were compared: 1) clinical data using Centers for Disease Control criteria; 2) blind protected bronchoalveolar lavage, evaluating quantitative cultures, bacterial index of >5, Gram stain, and presence of intracellular bacteria; and 3) nonquantitative cultures of endotracheal secretions. The reference standard used was clinical judgment of three independent experts (Delphi method) who retrospectively established by consensus the presence of ventilator-associated pneumonia based on clinical, microbiological, and radiologic data. Concordance between each diagnostic method and the reference standard was evaluated by concordance percentage and kappa score. Validity was evaluated using sensitivity, specificity, positive predictive value, negative predictive value, and global value.

Results A total of 30 patients were included in the study. According to the reference standard, ventilator-associated pneumonia occurred in 10 of 30 patients (33%). Bacterial index of >5 in bronchoalveolar secretions showed the best concordance compared with the reference standard (concordance, 83%; kappa, 0.61). Bacterial index of >5 also showed the best validity (sensitivity, 78%; specificity, 86%; positive predictive value, 70%; negative predictive value, 90%; global value, 90%). Intracellular bacteria and Gram stain from bronchoalveolar secretions were very specific (95% and 81%, respectively) but not sensitive (30% and 50%, respectively). Clinical criteria and endotracheal cultures were very sensitive (100% and 90%, respectively) but poorly specific (15% and 40%, respectively).

Conclusion Our data show that the most reliable diagnostic method for ventilator-associated pneumonia is a bacterial index of >5, using blind protected bronchoalveolar lavage. Further studies should evaluate the validity of all these methods according to the gold standard (autopsy).

Pediatric Intensivist, Hópital Sainte-Justine (FG), Professor, Department of Social Preventive Medicine, University of Montreal (CD), Clinical Assistant Professor, Department of Pediatrics, Univeristy of Sherbrooke—Canada (MC), Associate Professor, University of Montreal, Ste. Justine Hospital (FP), Associate Clinical Professor, Université de Montréal, Pediatric Intensivist, Hópital Sainte-Justine (CAF), Professor, Department of Pediatrics, Université de Montréal, Sainte-Justine Hospital (JL), Montreal, Quebec, Canada.

LEARNING OBJECTIVES

On completion of this article, the reader should be able to:

1. Identify risk factors associated with ventilator-associated pneumonia.

2. Identify parameters in bronchoalveolar lavage that demonstrate the best concordance with ventilator-associated pneumonia.

3. Identify parameters that are associated with the use of a blind protected bronchoalveolar lavage.

Dr. Farrell is the recipient of research/grant funding from Eli Lilly & Company/Canada. The remaining authors have disclosed that they have no financial relationships with commercial companies pertaining to this educational activity.

Visit the Pediatric Critical Care Medicine Online website (http://www.pccmjournal.com) for information on obtaining continuing medical education credit.

Supported, in part, by the Fondation de l’Hôpital Sainte-Justine.

*:See also p. 492.

©2003The Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies