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TWO CASES OF ORAL PLASMABLASTIC LYMPHOMA

Gordon, Anne; Talacko, Anna; Aldred, Michael; Kung, Ignatius

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Pathology - Journal of the RCPA: 2010 - Volume 42 - Issue - p S14
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A 54‐year‐old male presented with a large exophytic bluish lesion in the right mandibular alveolus. The patient had received a kidney transplant in 2001 and was on immunosuppressant medication. An incisional biopsy was submitted for histological examination. On light microscopy, the specimen comprised mature fibrous connective tissue which was diffusely infiltrated by a population of dissociated neoplastic cells, many of which had a plasmacytoid appearance. A variety of immunohistochemical stains were performed. We concluded that this was a malignant poorly differentiated non‐epithelial tumour that could not be further classified at that time.

A 67‐year‐old male presented with a 2.5 × 2.0 cm soft tissue swelling in the right side of the palate. The patient was a diabetic and had a history of a liver transplant. A biopsy specimen was submitted for histological examination. Microscopic examination revealed that the specimen was composed almost entirely of neoplastic lymphoid cells, some of which had a plasmacytoid appearance.

In both cases, the immunohistochemical findings together with the cytomorphology were consistent with a diagnosis of a post‐transplantation lymphoproliferative disorder. Confirmation of the presence of Epstein–Barr virus by in situ hybridisation added further support to the diagnosis of plasmablastic lymphoma.

© 2010 Royal College of Pathologists of Australasia