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EVALUATION OF LIVER SPECIFIC AUTOANTIGENS IN CLINICAL PRACTICE

Wienholt, L.1; Adelstein, S.1; McCaughan, G.2; AlGhamdi, H.2

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Pathology - Journal of the RCPA: 2010 - Volume 42 - Issue - p S48
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The identification of patients with autoimmune liver conditions partially relies on the presence of disease specific autoantibodies, which can be detected using a number of assay and methodologies.

We evaluated the performance of six commercial liver‐specific assays in the characterisation of 90 patients with undiagnosed liver disease referred to a tertiary referral liver clinic. The patients were clinically characterised by criteria developed by the International Autoimmune Hepatitis Group1 and the simplified criteria for the diagnosis of autoimmune hepatitis2 and liver biopsy where appropriate.

Of the 42 patients who were clinically characterised as having a definite or probable autoimmune liver disease 27 (64%) had a least one autoantibody detected, compare with 14/48 (29%) of disease controls.

The antigen specificities and diagnostic significance will be discussed.

References

1. Alvarez F, Berg PA, Bianchi FB, et al. International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis. J Hepatol 1999; 31: 929-938.
2. Hennes EM, Zeniya M, Czaja AJ, et al. Simplified criteria for the diagnosis of autoimmune hepatitis. Hepatology 2008; 48: 169-176.
© 2010 Royal College of Pathologists of Australasia