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The changing face of GIST: implications for pathologists

Hemmings, Chris1,2; Yip, Desmond3,4

doi: 10.1097/PAT.0000000000000047
Soft Tissue Pathology

Summary: Gastrointestinal stromal tumour (GIST) is now recognised as the most common primary mesenchymal tumour of the gut. A number of different parameters have been identified to aid prediction of clinical behaviour, but prognostication for an individual remains difficult. The pathologist plays a crucial role in guiding management of these tumours, but is faced with a number of challenges in so doing. This review describes the variable pathological features that may be encountered, and examines some of the issues in the pathology reporting of GIST and attempts to provide some guidance in factors that should be addressed in a comprehensive pathology report.

1St John of God Pathology Subiaco

2School of Surgery, University of Western Australia, Western Australia

3Department of Medical Oncology, The Canberra Hospital

4ANU Medical School, Australian National University, Canberra, Australian Capital Territory, Australia

Address for correspondence: Dr C. Hemmings, SJOG Pathology, Level 5, Bendat Family Comprehensive Cancer Centre, 12 Salvado Rd, Subiaco, WA 6008, Australia. E-mail:

Received 5 September, 2013

Accepted 15 September, 2013

© 2014 Royal College of Pathologists of Australasia
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