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New Topics in Anatomic Pathology

Yeh, I-Tien MD

doi: 10.1097/PCR.0b013e31812565d1

From the Department of Pathology, University of Texas Health Science Center, San Antonio, Texas.

Reprints: I-Tien Yeh, MD, Department of Pathology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229. E-mail:

Although the typical format of Pathology Case Reviews focuses on a single organ, this issue includes articles spanning multiple organs. We present a series of newly recognized lesions that are changing our views of common tumors, as well as new ways of looking at previously recognized entities.

This issue begins with a new look at polyps of the colon. In past years, we have simply divided polyps into hyperplastic and adenomatous, with the idea that hyperplastic polyps are non-neoplastic and adenomatous polyps are precancerous. There is recent evidence that some polyps that look like hyperplastic polyps, but with some special features—the serrated polyps—are also likely to be precancerous. The review by Drs. Al-Daraji and Montgomery clarifies the features between the usual hyperplastic polyps and the serrated polyps.

In the second article of this issue Drs. Jeffrey Seidman and Varallo review micropapillary serous carcinoma of the ovary, an entity that was previously classified as either borderline serous or well-differentiated serous carcinoma of the ovary. The authors feel the term borderline is archaic and propose a new classification of serous tumors of the ovary with micropapillary architecture.

We then present a case of a basal-like carcinoma of the breast, written by my colleague from across town in San Antonio, Dr. Oluwole Fadare, and myself. These tumors have garnered much attention in recent years as a result of molecular classification of breast cancer. Classifying a breast cancer as basal-like also has prognostic and therapeutic implications. We describe an immunophenotypic basal-like breast cancer and review the current literature on these tumors.

Next, Dr. Guindi presents a newly recognized variant of hepatic adenoma that shifts our thinking about hepatic adenomas as lacking ductules. This new entity, the telangiectatic focal nodular hyperplasia, is considered a heptatic adenoma, yet contains ductular elements.

When we hear the term phyllodes tumor, we automatically think of the breast lesion by that name. However, phyllodes tumor may also occur in the prostate, and Drs. Bostwick, Meiers, and Hossain present such a case and give us the differential diagnosis and update the classification of prostatic soft tissue tumors.

The last 2 articles delineate cytologic diagnoses made by relatively new types of cytologic specimens: endometrial cytology using the Tao brush and endoscopic ultrasound-guided fine needle aspiration cytology. Drs. Bishop and Maksem illustrate a case of endometrial intraepithelial neoplasia, the in situ form of serous endometrial carcinoma. Drs. Jhala, Siegal, and Jhala present a case of solid pseudopapillary neoplasm of the pancreas.



© 2007 Lippincott Williams & Wilkins, Inc.