Case Review: PDF OnlyLarge-Cell Neuroendocrine Carcinoma of the Prostate A Case Presentation and Review of LiteratureYeh, Yunshin Albert MD, PhD*,†; Constantinescu, Michael MD*; Chaudoir, Catherine MD*; Tanner, Anthony MS*; Yang, Shu MD‡; Serkin, Faye B. MD†,§; Fazili, Tajammul MD†,§; Yu, Xiuping PhD†,‡; Lurie, Aubrey A. MD* Author Information From the *Pathology and Laboratory Medicine Service, Overton Brooks VA Medical Center Departments of †Urology ‡Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center §Urology Division of Surgery Service, Overton Brooks VA Medical Center, Shreveport, LA. Reprints: Yunshin Albert Yeh, MD, PhD, Pathology and Laboratory Medicine Service, Overton Brooks VA Medical Center, 510 E Stoner Ave, Shreveport, LA 71101. E-mail: [email protected]. This study is supported by National Institutes of Health grant R01 CA226285 to Dr. X.Y. The authors have no conflicts to declare. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. AJSP: Reviews & Reports: May 6, 2021 - Volume - Issue - doi: 10.1097/PCR.0000000000000441 Open PAP Metrics Abstract Primary large-cell neuroendocrine carcinoma of the prostate is very rare. The tumor genomic alterations have not been reported. We report a case of a 78-year-old man with a recurrent large-cell prostatic neuroendocrine carcinoma with distinctive pathological features and genetic changes including ATM frameshift duplication, TP53 missense mutation, and a chromosomal translocation leading to STAG2-BTD gene fusion. © 2022 Lippincott Williams & Wilkins, Inc.