ReviewsCounterpoint: Integration of Molecular Subtype and Histotype/Grade Into One Classification System for Endometrial CarcinomaKöbel, Martin MD Author Information From the Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada. Reprints: Martin Köbel, MD, Department of Pathology and Laboratory Medicine, Foothills Medical Centre, McCaig #7551, 1403 29 St NW, Calgary, Alberta, Canada T3N2T9. E-mail: [email protected]. The author has no funding or conflicts to declare. AJSP: Reviews & Reports: 9/10 2022 - Volume 27 - Issue 5 - p 187-197 doi: 10.1097/PCR.0000000000000529 Buy Metrics Abstract The establishment of 4 endometrial carcinoma molecular subtypes by The Cancer Genome Atlas project and their surrogates (POLE mutated, mismatch repair–deficient, p53 abnormal, and no specific molecular profile) invigorated a debate on how to integrate these within the traditional histotype/grade classification. Specific issues of contradicting histotype/grade and molecular subtype diagnoses will be discussed with illustrated examples. The hierarchy of histotype/grade and molecular subtype is interdependent. Pathologists should aim to integrate histotypes/grades and molecular subtypes to provide one consistent and clinically relevant diagnosis. Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.