ReviewsDoing More With Fewer: Optimizing Value With Limited Numbers of AutopsiesWilliamson, Alex K. MDAuthor Information From the Department of Pathology & Laboratory Medicine, Zucker School of Medicine at Hofstra/Northwell, Hempstead; and Department of Pathology, LIJ Medical Center, New Hyde Park, NY. Reprints: Alex K. Williamson, MD, Department of Pathology, LIJ Medical Center, 270-05 76th Ave #B68, New Hyde Park, NY 11040. E-mail: [email protected]. This review was not supported by any external funding source. A.K.W. receives royalties from Springer Nature Switzerland AG for editing Autopsy in the 21st Century: Best Practices and Future Directions. This manuscript represents original work and is not under consideration for publication elsewhere. No figures are being reprinted from other sources. The author has no funding or conflicts to declare. AJSP: Reviews & Reports: 3/4 2021 - Volume 26 - Issue 2 - p 79-92 doi: 10.1097/PCR.0000000000000433 Buy Metrics Abstract The value of autopsy is best demonstrated when the procedure is competently practiced in an appropriate clinical setting. Autopsy performance is expectedly restricted when a death raises certain forensic, religious, legal, or safety concerns. Additionally, limiting the scope of postmortem examinations to deaths that fulfill various clinical indications for the procedure will be important moving forward. This is especially true as institutions that finance autopsy services face uncertain and likely difficult financial conditions in the wake of the coronavirus disease 2019 pandemic. Autopsy pathologists should actively engage with clinicians in promoting responsible autopsy practice and delivering quality postmortem care. Using a problem-oriented autopsy record, thoughtfully evaluating postmortem histology, and purposefully reporting autopsy findings can help pathologists provide valuable data to autopsy's various stakeholders. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.