ReviewSinonasal Mucoepidermoid Carcinoma: A Brief Review of LiteratureMiddleton, Charles E. IV MD; Manucha, Varsha MDAuthor Information From the Department of Pathology, University of Mississippi Medical Center, Jackson, MS. Reprints: Charles E. Middleton IV, MD, Department of Pathology, University of Mississippi Medical Center, 2500 N State St, Jackson, MS 39216. E-mail: [email protected]. The authors have no funding or conflicts to declare. AJSP: Reviews & Reports: 11/12 2020 - Volume 25 - Issue 6 - p 306-309 doi: 10.1097/PCR.0000000000000415 Buy Metrics Abstract Objective Review the clinical, histologic, and molecular features of sinonasal mucoepidermoid carcinoma (SN-MEC) with emphasis on the application and prognostic significance of MAML2 rearrangement. Main points Location of MEC in the sinonasal region accounts for less than 0.1% of primary sinonasal malignancies. Primary SN-MEC most commonly affects the maxillary sinuses, and the mean age at diagnosis is 57 years. MAML2 translocation status aids in diagnosis but has no bearing on prognosis. The most significant prognostic criteria for SN-MEC are older age, tumor size gerater than 4 cm, higher grade, and advanced American Joint Committee on Cancer stage. Conclusions SN-MEC is a rare entity that presents at a higher grade and has lower 5-year disease-specific survival when compared with MEC of the major salivary glands. Correct recognition is important because of the impact on clinical management and prognosis. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.