Case ReviewPrimary Extranodal Classical Hodgkin Lymphoma of the Sphenoid Sinus: A Case Report and Brief Review of the LiteratureOdeyemi, Olumide O. MD; Rosser, Julie A. DOAuthor Information From the University of Colorado Anschutz Medical Campus, Aurora, CO. Reprints: Olumide O. Odeyemi, MD, Department of Pathology, University of Colorado, Box B216, 12631 E 17th Ave, Aurora, CO 80045. E-mail: [email protected]. The authors have disclosed that they have no significant relationships with, or financial interest in, any commercial companies pertaining to this article. AJSP: Reviews & Reports: 11/12 2020 - Volume 25 - Issue 6 - p e13-e16 doi: 10.1097/PCR.0000000000000374 Buy Metrics Abstract Primary sinonasal lymphoma is a relatively rare disease, particularly in Western societies, and the vast majority of these are non-Hodgkin lymphoma. Classical Hodgkin lymphoma (CHL) characteristically originates in lymph nodes; primary extranodal CHL of the sinonasal tract is extremely rare. We report a case of a 63-year-old woman with primary CHL of the sphenoid sinus. The patient presented to the emergency department with complaints of “flashing light” in both eyes. Magnetic resonance imaging studies revealed a 4.2-cm enhancing mass in the sphenoid sinus. Histologic examination of the sphenoid mass revealed a diffuse mixed inflammatory infiltrate, within which were scattered large atypical cells with enlarged nuclei with irregular nuclear contours and prominent eosinophilic nucleoli, consistent with Hodgkin/Reed-Sternberg cells. Immunohistochemical studies showed the large atypical cells to be positive for CD15 and CD30 and negative for CD20 and CD45. In situ hybridization staining for small Epstein-Barr virus–encoded RNA was also positive in the atypical cells. These findings supported the diagnosis of CHL. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.