Case ReviewsA Guide to Differentiating Thrombotic Microangiopathies Through a Case of Catastrophic Antiphospholipid SyndromeHardy, Naomi MD; Stashek, Kristen MDAuthor Information From the University of Maryland School of Medicine, Baltimore, MD. Reprints: Naomi Hardy, MD, University of Maryland, Anatomic Pathology, 22 S. Greene St, Baltimore MD 21201. E-mail: [email protected]. The authors have no funding or conflicts to declare. AJSP: Reviews & Reports: 11/12 2020 - Volume 25 - Issue 6 - p 266-269 doi: 10.1097/PCR.0000000000000417 Buy Metrics Abstract Thrombotic microangiopathies are rare life-threatening diseases that require prompt diagnosis and treatment to increase patient survival. The prototypical thrombotic microangiopathies are classic hemolytic-uremic syndrome, caused by enterohemorrhagic Escherichia coli, and thrombotic thrombocytopenic purpura. Included in the differential diagnoses and showing overlapping clinical features is antiphospholipid syndrome (APS) and the more severe form, catastrophic APS. Here, we discuss the general approach to thrombotic microangiopathies through a case of APS that later developed into its catastrophic variant. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.