ReviewDiagnosing Recently Defined and Uncommon Salivary Gland Lesions in Limited Cellularity Specimens: Cytomorphology and Ancillary StudiesRossi, Esther Diana MD, PhD, MIAC∗; Baloch, Zubair MD†; Faquin, William MD, PhD‡; Pantanowitz, Liron MD§Author Information From the ∗Division of Anatomic Pathology and Histology, Catholic University of Sacred Heart, Rome, Italy †Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA ‡Department of Pathology, Massachusetts General Hospital, Boston, MA §Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA. Reprints: Esther Diana Rossi, MD, PhD, MIAC, Catholic University of Scared Heart, Rome, Italy. E-mail: firstname.lastname@example.org. All the authors equally contributed to the article. The authors have no funding or conflicts to declare. AJSP: Reviews & Reports: 9/10 2020 - Volume 25 - Issue 5 - p 210-219 doi: 10.1097/PCR.0000000000000399 Buy Metrics Abstract Fine-needle aspiration (FNA) has proven to be an essential step in the preoperative evaluation of patients with salivary gland lesions. The diagnosis rendered on FNA specimens helps streamline clinical and/or surgical management. However, despite its usefulness, FNA has known limitations. Fine-needle aspiration may fail to provide a specific diagnosis in some cases because of limited aspirated material, cellular makeup, and/or morphologic heterogeneity. The field of salivary gland pathology is rapidly changing because of the identification of new entities and reclassification of existing lesions based on morphologic features and emerging antigenic and molecular profiles. A management-based cytological diagnosis of these newly reclassified and/or uncommon neoplasms is possible using characteristic morphologic features and specific translocations. Herein, we review the salient morphologic features, immunohistochemistry, and molecular profile of several recently described salivary gland neoplasms in light of clinical management. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.