Case ReviewsProstatic Carcinoma With Aberrant Expression of p63 A Case Report and Review of the LiteraturePaulk, Adina MD*; McCool, Isaac MD†; Sesterhenn, Isabell MD*; Burke, Allen MD‡Author Information From the *Joint Pathology Center, Silver Spring †Walter Reed National Military Medical Center, Bethesda ‡University of Maryland Medical Center, Baltimore MD. Reprints: Adina Paulk, MD, Joint Pathology Center, 606 Stephen Sitter Ave, Silver Spring, MD 20910. E-mail: Adina.T.Paulk.firstname.lastname@example.org. The authors have no funding or conflicts to declare. The views expressed in this article are those of the authors and do not reflect the official policy of the Department of Army/Navy/Air Force, Department of Defense, or the US Government. AJSP: Reviews & Reports: May/June 2020 - Volume 25 - Issue 3 - p 129-132 doi: 10.1097/PCR.0000000000000378 Buy Metrics Abstract Prostatic carcinoma with aberrant expression of p63 is a rare variant of prostate cancer, which represents a potential diagnostic pitfall, as it may be easily confused with either benign prostatic glands or high-grade prostatic carcinoma. In studies of radical prostatectomies, these tumors appear to behave like low-grade carcinomas despite frequent poorly formed architecture. We report a case of prostatic carcinoma with aberrant expression of p63 with a review of the literature and helpful features in the differential diagnosis of this entity. © 2020 Lippincott Williams & Wilkins, Inc.