Case ReviewsHistopathologic Changes in a Hypogonadal Male on Exogenous Testosterone Diagnosed With Prostatic Adenocarcinoma A Case ReportYang, David MD, MPH; Sun, Yue MDAuthor Information From the Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA. Reprints: Yue Sun, MD, Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA, 02215. E-mail: firstname.lastname@example.org. The authors have no funding or conflicts to declare. AJSP: Reviews & Reports: May/June 2020 - Volume 25 - Issue 3 - p 127-128 doi: 10.1097/PCR.0000000000000381 Buy Metrics Abstract In the United States, prostatic adenocarcinoma is the most common nonskin cancer and second leading cause of cancer death. Pathologic diagnostics are paramount to guiding treatment but require an awareness that hormonal treatments have the capacity to alter the histological appearance of prostate cancer. This case highlights the importance of accurate diagnostics and grading through a discussion of histological findings in an unusual case of a male patient with hypogonadism on long-term exogenous testosterone who was diagnosed with prostatic adenocarcinoma. © 2020 Lippincott Williams & Wilkins, Inc.