Case ReviewsBlue Nevus of the Prostate A Report of Two Cases and Review of the LiteratureLegesse, Teklu MD; Sesterhenn, Isabell MD; Paulk, Adina MDAuthor Information From the University of Maryland Medical Center, Baltimore, MD. Reprints: Teklu Legesse, MD, University of Maryland School of Medicine, 22 S Greene St, Baltimore, MD 21201. E-mail: email@example.com. The views expressed in this article are those of the author and do not reflect the official policy of the Department of Army/Navy/Air Force, Department of Defense, or the US Government. The authors have no funding or conflicts to declare. AJSP: Reviews & Reports: May/June 2020 - Volume 25 - Issue 3 - p 144-146 doi: 10.1097/PCR.0000000000000383 Buy Metrics Abstract Pigmented lesions of the prostate are very rare and include melanosis, blue nevus, and malignant melanoma. Of these lesions, blue nevus (also known as pigmented melanocytosis or pigmentary nevohyperplasia) is the most frequently reported one. It is morphologically similar to its much more common cutaneous counterpart and composed mainly of heavily pigmented spindle cells within the prostatic stroma. It is often discovered incidentally in needle biopsies, transurethral resection of the prostate, or prostatectomy specimens performed for prostatic cancer or benign prostatic hyperplasia. It is a benign lesion with no potential for malignant transformation. Recognition of this entity is important because of the differential diagnosis with the much rarer malignant melanoma involving the prostate. The pathologic features and differential diagnosis with relevant literature review are discussed in this report. © 2020 Lippincott Williams & Wilkins, Inc.