Case ReviewsHigh-Grade Gliomas in Early Adulthood A Case-Based Review of Current Molecular Diagnostic ConsiderationsCanbeldek, Leyla MD*; Ames, Heather M. MD, PhD*,†,‡Author Information From the Departments of *Pathology †Anatomy and Neurobiology ‡Greenbaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD. Reprints: Heather M. Ames, MD, PhD, University of Maryland Medical Center, 22 South Greene St, NBW43 Baltimore, MD 21201. E-mail: firstname.lastname@example.org. The authors have no funding or conflicts to declare. AJSP: Reviews & Reports: March/April 2020 - Volume 25 - Issue 2 - p 63-68 doi: 10.1097/PCR.0000000000000371 Buy Metrics Abstract High-grade gliomas in early adulthood (between the ages of 20 and 40 years) have a wide differential diagnosis that includes entities from childhood and late adulthood. These gliomas are increasingly defined by their molecular signatures, requiring a molecular-based workup that is informed by morphology and anatomy. Here we present four cases with four different diagnoses, some rare and some common, presenting with new brain lesions. This diagnostic process is informed by the 2016 World Health Organization guidelines, c-IMPACT Now updates, and the clinico-pathologic features shown by these high-grade tumors. Particularly, we focus on practical diagnostic decisions that may need to be made with limited tissue and/or limited on-site molecular resources. © 2020 Lippincott Williams & Wilkins, Inc.