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Granulomatous Slack Skin T-Cell Lymphoma Manifesting as Ulcerative and Gangrenous Lesions With a Fatal Outcome

A Case Report and Review of the Literature

Su, Ruijun Jeanna MD, PhD*; Said, Jonathan MD*; Kallen, Michael E. MD; Jumniensuk, Chayanit MD; Pullarkat, Sheeja MD*

doi: 10.1097/PCR.0000000000000339
Case Reviews
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Granulomatous slack skin is an extremely rare cutaneous T-cell lymphoma, which often pursues an indolent disease course. Clinically, it is characterized by areas of redundant and lax skin in flexural areas, with variable erythema. Histologic findings include granulomatous T-cell infiltrates with loss of elastic fibers and poikilodermic change. In this article, we report a patient with unusual rapidly progressive ulcerative and gangrenous skin lesions, leading to amputation and ultimately demise. We also review the literature on granulomatous slack skin with similarly aggressive clinical course and discuss the differential diagnosis.

From the *Department of Pathology and Laboratory Medicine, University of California at Los Angeles, David Geffen School of Medicine, Los Angeles, CA

Department of Pathology, University of Maryland School of Medicine, Baltimore, MD

Department of Pathology, Army Institute of Pathology, Bangkok, Thailand.

Reprints: Sheeja Pullarkat, MD, University of California at Los Angeles, David Geffen School of Medicine, 10833 Le Conte Ave, Los Angeles, CA 90095. E-mail: spullarkat@mednet.ucla.edu.

The authors have no funding or conflicts to declare.

© 2019 Lippincott Williams & Wilkins, Inc.