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Transformed Mycosis Fungoides and Mimics

Exploring the Landscape of CD30+ Cutaneous T-Cell Lymphomas

Merechi, Fikru MD; Koka, Rima MD, PhD; Singh, Zeba MBBS; Lee, Seung Tae MD; Kallen, Michael E. MD

doi: 10.1097/PCR.0000000000000324
Case Reviews

Mycosis fungoides (MF) is an epidermotropic, primary cutaneous T-cell lymphoma (CTCL) with a generally indolent clinical course, although higher stage and transformed tumors can behave more aggressively. Large cell transformation may demonstrate CD30 expression and histologically resemble other CD30+ CTCLs, including lymphomatoid papulomatosis and cutaneous anaplastic large cell lymphoma. These entities are thought to exist on a spectrum with overlapping histologic features; however, it is of clinical importance that we do our best to accurately classify these entities due to the variability in treatment and prognosis. In this report, we present a case of CD30+ transformed MF and discuss the clues that allow us to make the challenging distinction between transformed MF and other CD30+ CTCLs. We review histologic and clinical features of these different disorders, with a focus on the revised World Health Organization classification of primary cutaneous lymphomas.

From the Department of Pathology, University of Maryland School of Medicine, Baltimore, MD.

Reprints: Michael E. Kallen, MD, Department of Pathology, University of Maryland School of Medicine, 22 S Greene St, Baltimore, MD 21201. E-mail:

The authors have no funding or conflicts to declare.

© 2019 Lippincott Williams & Wilkins, Inc.