Posttransplant Classic Hodgkin Lymphoma Richter Transformation or Posttransplant Lymphoproliferative Disorder?Lee, Ina MD, PhD*; Zou, Ying MD, PhD*; Hodges, Susan NP†; Rapoport, Aaron P. MD†; Hardy, Nancy MD†; Singh, Zeba MBBS*AJSP: Reviews & Reports: September/October 2019 - Volume 24 - Issue 5 - p 212–217 doi: 10.1097/PCR.0000000000000333 Case Reviews Buy Abstract Author InformationAuthors Article MetricsMetrics Richter transformation (RT) is defined as the transformation of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) into high-grade lymphoma. An average of 5% of patients with CLL/SLL will have disease that undergoes RT during their clinical course. While most (75%) of these transformed cases manifest as diffuse large B-cell lymphoma, other variants occur, including a small minority (0.4%–0.7%) that progress to a classic Hodgkin lymphoma variant. Richter transformation portends a poor outcome in comparison to nontransformed CLL/SLL. Allogeneic stem cell transplantation (allo-SCT) can be offered, with a 5-year survival rate of 50% to 70%. In addition to disease relapse, transplantation carries significant risk of nonrelapse morbidity, including posttransplant lymphoproliferative disorder (PTLD). The distinction between disease progression or recurrence and PTLD can be challenging and has critical prognostic and therapeutic implications. In this report, we describe a patient whose initial CLL/SLL transformed to diffuse large B-cell lymphoma, who then received allo-SCT. Subsequent development of classic Hodgkin lymphoma proved to be a diagnostic conundrum, for which PTLD and disease progression/recurrence were both reasonable considerations. This case illustrates the diagnostic dilemma and semantic confusion faced by both pathologists and clinicians when lymphoproliferative disorders emerge within the immunologically complex interface of CLL/SLL, RT, and allo-SCT. As molecular technologies are becoming more commonplace in routine diagnostics, subpopulation clonal analysis may be useful in such cases. It may also be worth reevaluating the classification and criteria for PTLD and different subtypes of RT, especially in light of implications for prognosis and optimal therapies. From the *Department of Pathology †Hematology and Oncology, Department of Medicine and Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD. Reprints: Zeba Singh, MBBS, Department of Pathology, University of Maryland School of Medicine, and University of Maryland Medical Center, 22 S Greene St, Baltimore, MD 21201. E-mail: email@example.com. The authors have no funding or conflicts to declare. © 2019 Lippincott Williams & Wilkins, Inc.