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The Molecular Pathology of Appendiceal Neoplasms

Leeming, Amy, BMBCh, BSc(Hons); Worrall, David, MBChB, BSc(Hons), FRCPath; Arends, Mark Johan, PhD, MBChB(Hons), BSc(Hons), FRCPath

doi: 10.1097/PCR.0000000000000304

We review the molecular pathological changes of appendiceal neoplasms, in part using the consensus terminology agreed by the Peritoneal Surface Oncology Group International (Am J Surg Pathol 2016;40(1):14–26; Histopathology 2017;71(6):847–858), with appendiceal neoplasms subcategorized as hyperplastic polyps and serrated lesions (with and without dysplasia), appendiceal mucinous neoplasms (low and high grade), adenocarcinoma, goblet cell tumors, and neuroendocrine neoplasms.

From the Division of Pathology, University of Edinburgh; and Pathology Department, Western General Hospital, Edinburgh, United Kingdom.

Reprints: Mark Johan Arends, PhD, MBChB(Hons), BSc(Hons), FRCPath, Division of Pathology, University of Edinburgh, Institute of Genetics and Molecular Medicine, Crewe Road, Edinburgh, EH4 2XR, Edinburgh, United Kingdom. E-mail:

The authors have no funding or conflicts to declare.

© 2019 Lippincott Williams & Wilkins, Inc.