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Sarcomatoid Hepatocellular Carcinoma

A Case Report and Review of the Differential Diagnosis of Malignant Spindle Cell Lesions of the Liver

Stashek, Kristen M., MD*; White, Rachel, MD*; Song, Linda, MD*; Tondon, Rashmi, MD; Kallen, Michael, MD*; Twaddell, William, MD*

doi: 10.1097/PCR.0000000000000293
Case Reports

Sarcomatoid hepatocellular carcinoma is a rare aggressive variant of hepatocellular carcinoma that typically shows a conventional component of hepatocellular carcinoma admixed with a malignant spindle cell proliferation. In small biopsy specimens, the conventional component may not always be present; therefore, knowledge of the differential diagnosis of malignant spindle cell lesion presenting in the liver is necessary to ensure accurate diagnosis.

From the *Department of Pathology, University of Maryland School of Medicine, Baltimore, MD; and

Department of Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

Reprints: Kristen M. Stashek, MD, Department of Pathology, University of Maryland School of Medicine, 22 S Greene St, Baltimore, MD 21201. E-mail:

The authors have no funding or conflicts to declare.

© 2019 Lippincott Williams & Wilkins, Inc.