Endometrial Stromal Sarcoma With High-Grade Morphology and a JAZF1 Gene Rearrangement Presenting as Colonic and Cardiac Metastases A Case Report and Review of the LiteratureJenkins, Taylor M., MD; Cooper, Kumarasen, MBChB, DPhil; Carolina Reyes, M., MD; Deshpande, Charuhas, MD; Staats, Paul N., MD; Schwartz, Lauren E., MD; Stashek, Kristen M., MDAJSP: Reviews & Reports: January/February 2019 - Volume 24 - Issue 1 - p 31–34 doi: 10.1097/PCR.0000000000000290 Case Reports Buy SDC Abstract Author InformationAuthors Article MetricsMetrics Endometrial stromal tumors are a heterogeneous group of tumors with varied histologies and molecular alterations. JAZF1 rearrangements are typically characteristic of low-grade lesions, high-grade lesions usually harbor YWHAE alterations, and undifferentiated uterine sarcomas commonly present with complex karyotypes. We report a case of an endometrial stromal sarcoma with a JAZF1 gene rearrangement by fluorescence in situ hybridization and high-grade cytology presenting as cardiac and colonic metastases, in a patient with a remote history of hysterectomy for to “leiomyomas.” From the Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA. Reprints: Taylor M. Jenkins, MD, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104. E-mail: firstname.lastname@example.org. The authors have no funding or conflicts to declare. © 2019 Lippincott Williams & Wilkins, Inc.