Mucinous Tubular and Spindle Cell Carcinoma: Case Report and Review of an Uncommon Renal TumorUdager, Aaron M. MD, PhD*; Dhanasekaran, Saravana M. PhD†; Mehra, Rohit MD*†‡AJSP: Reviews & Reports: November/December 2017 - Volume 22 - Issue 6 - p 297–300 doi: 10.1097/PCR.0000000000000218 Case Reviews Buy Abstract Author InformationAuthors Article MetricsMetrics Mucinous tubular and spindle cell carcinoma (MTSCC) is an uncommon renal tumor with characteristic morphologic features but overlapping immunophenotype with papillary renal cell carcinoma. Recent genomic and transcriptomic analysis of MTSCC has uncovered recurrent chromosomal losses and frequent biallelic alteration of Hippo pathway genes, resulting in increased YAP1 nuclear expression. In this article, we describe a case of MTSCC and review the pertinent clinical, morphologic, immunohistochemical, and molecular findings of this uncommon kidney tumor. In the era of personalized medicine, increased pathologic recognition of MTSCC may facilitate targeted therapeutic approaches (ie, the YAP1 small molecule inhibitor verteporfin) for rare patients with aggressive tumors. From the *Department of Pathology, University of Michigan Medical School; †Michigan Center for Translational Pathology; and ‡Comprehensive Cancer Center, Michigan Medicine, Ann Arbor, MI. Reprints: Rohit Mehra, MD, Department of Pathology, University of Michigan Medical School, 2G332 UH, 1500 E Medical Center Dr, Ann Arbor, MI 48109. E-mail: firstname.lastname@example.org. The authors have no funding or conflicts to declare. © 2017 Lippincott Williams & Wilkins, Inc.