The differential diagnosis of clear cell tumors within the jawbones can be challenging and includes various odontogenic, salivary, and metastatic tumor types. In this review, we discuss the following diagnostic considerations: calcifying epithelial odontogenic tumor, clear cell odontogenic carcinoma, odontogenic carcinoma with dentinoid, primary intraosseous mucoepidermoid carcinoma, primary intraosseous squamous cell carcinoma, and metastases to the jawbones. In particular, we highlight helpful diagnostic features, recent advances, and areas of controversy.
From the *Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA; and †Division of Oral Pathology, College of Dental Medicine, Medical University of South Carolina, Charleston, SC.
Reprints: Angela C. Chi, DMD, Division of Oral Pathology, College of Dental Medicine, Medical University of South Carolina, 173 Ashley Ave, MSC 507, Charleston, SC 29425. E-mail: email@example.com.
The authors have no funding or conflicts to declare. In the interest of full disclosure, Dr Chi reports royalties from Elsevier for coauthoring the textbook Oral and Maxillofacial Pathology.