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c-Myc Immunohistochemistry in Diffuse Large B Cell Lymphoma

Gocke, Christopher D. MD

doi: 10.1097/PCR.0000000000000058
Case Reviews

Diffuse large B cell lymphoma is a collection of different biologic entities with a common appearance but different clinical behaviors. The MYC oncogene is mutated in a subset of diffuse large B cell lymphoma and is also mutated in related entities such as Burkitt lymphoma. Recently, an antibody to the c-Myc oncoprotein has become available for immunohistochemistry, raising the possibility of a rapid, reproducible and inexpensive measure of MYC abnormality. Initial retrospective studies of these lymphomas suggest that the c-Myc status is clinically important for diagnosis and prognosis, particularly when used in conjunction with BCL2 immunohistochemistry. It is possible that therapy will be modified based in part on c-Myc status, once the appropriate prospective studies have been performed.

From the Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD.

Reprints: Christopher D. Gocke, MD, Associate Professor, Department of Pathology, Johns Hopkins University School of Medicine, 600 N Wolfe St/Park SB202, Baltimore, MD 21287. E-mail:

The authors have no funding or conflicts to declare.

© 2014 by Lippincott Williams & Wilkins.