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Prostate Cancer: Optimal Tissue Processing for Diagnosis and Prognosis

Meiers, Isabelle MD*; Bostwick, David G. MD, MBA

doi: 10.1097/PCR.0000000000000034

Optimal processing, handling, and sampling of prostatic biopsies and prostatectomy specimens ensure accurate diagnosis and staging. Prognostic factors derived from careful examination of tissue samples are critical for patient management, including cancer volume, extraprostatic extension, surgical margins, vascular/lymphatic invasion, and perineural invasion. This chapter addresses these important issues, including recent recommendations of a consensus panel of the International Society of Urological Pathology and the Union for International Cancer Control 2010 TNM Staging Committee.

From the *Bostwick Laboratories, London, England; and †Bostwick Laboratories, Orlando, FL.

Reprints: David G. Bostwick, MD, Bostwick Laboratories, Inc, Orlando, FL. E-mail:

The authors have no funding or conflicts to declare.

© 2014 by Lippincott Williams & Wilkins.