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High-Grade Prostatic Intraepithelial Neoplasia and Intraductal Carcinoma With Intraluminal Small Cell Features

Ma, Jun MD; Bostwick, David G. MD, MBA

doi: 10.1097/PCR.0000000000000031
Case Reviews

A rare and unusual pattern of intraluminal small cell proliferation may be found in high-grade prostatic intraepithelial neoplasia and intraductal carcinoma, raising the important concern for small cell carcinoma. Despite the presence of rosettes and occasional cases with neuroendocrine differentiation, this distinctive pattern does not usually coexist with small cell carcinoma and is considered at present to be of no clinical significance. This review describes this and other histopathologic patterns of high-grade prostatic intraepithelial neoplasia.

From Bostwick Laboratories, Inc, Orlando, FL.

Reprints: David G. Bostwick, MD, 6925 Lake Ellenor Drive, Suite 200, Orlando, FL 32809 VA. E-mail:

© 2014 by Lippincott Williams & Wilkins.