Case ReviewsDe Novo Autoimmune Hepatitis After Liver Transplantation for Hepatitis BTwaddell, William S. MDAuthor Information From the Department of Pathology, University of Maryland School of Medicine, Baltimore, MD. Reprints: William S. Twaddell, MD, Department of Pathology, University of Maryland School of Medicine 22 S. Greene St, NBS51 Baltimore, MD 21201. E-mail: [email protected]. The author has no funding or conflicts to declare. Pathology Case Reviews: November/December 2012 - Volume 17 - Issue 6 - p 248-251 doi: 10.1097/PCR.0b013e318275923b Buy Metrics Abstract De novo autoimmune hepatitis is a form of chronic hepatitis that occurs in patients after liver transplantation for reasons other than autoimmune hepatitis. Recognition of the disorder requires a high degree of vigilance on the parts of the treating clinicians and pathologists. Here, we report a case of a 54-year-old woman who developed liver dysfunction several years after transplantation for complications of hepatitis B. After liver biopsy, a diagnosis of de novo autoimmune hepatitis was established. The clinicopathological features of autoimmune and de novo autoimmune hepatitis are reviewed. The risk factors, possible pathogenetic mechanisms, and differential diagnosis of de novo autoimmune hepatitis are discussed. © 2012 Lippincott Williams & Wilkins, Inc.