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Simpson Jean F. MD; Carter, Beverley A. MD; Page, David L. MD
Pathology Case Reviews: September-October 1999

Several of the patterns of breast epithelial proligerative disease have been described as papillary, but the specific entity of intraductal papilloma is focus of this review. Epithelial proliferation often involves breast papillomas, and occasionally the patterns of hyperplasia are atypical. Specific criteria for epithelial hyperplasia with or without atypia are presented in the setting of a papilloma. Risk implications for a papilloma without atypical hyperplasia are similar to other nonatypical proliferative breast lesions (twice the risk of the reference population). The presence of atypical hyperplasia involving a papilloma indicates a greatly increased risk of local development of invasive mammary cascinoma, approximately 7 times the risk of patients with papillomas not showing atpia.

© 1999 Lippincott Williams & Wilkins, Inc.