Original ArticlesDecreased Mortality in Acute Pancreatitis Related to Early Aggressive HydrationWall, Ian DO; Badalov, Nison MD; Baradarian, Robin MD, FACG; Iswara, Kadirawel MD, FACG; Li, Jian Jun MD, FACG; Tenner, Scott MD, MPH, FACGAuthor Information From the Division of Gastroenterology, Department of Medicine, Maimonides Medical Center, State University of New York - Health Sciences Center, Brooklyn, NY. Received for publication June 19, 2010; accepted December 23, 2010. Reprints: Scott Tenner, MD, MPH, FACG, Medical Education and Research, Maimonides Medical Center, Associate Professor of Medicine, State University of New York - Health Sciences Center, 2211 Emmons Ave, Brooklyn, NY 11235 (e-mail: [email protected]). The authors have no conflicts of interest. All authors helped in data collection. Dr Wall was in charge of the initial article preparation. Drs Baradarian and Tenner were in charge of data analysis. Drs Iswara and Tenner were in charge of article preparation. Pancreas: May 2011 - Volume 40 - Issue 4 - p 547-550 doi: 10.1097/MPA.0b013e318215368d Buy Metrics Abstract Objective: Early aggressive intravenous hydration is believed to prevent morbidity and mortality by preventing intravascular volume depletion and maintaining perfusion of the pancreas possibly preventing pancreatic necrosis. The following study was initiated to determine the relationship between the observed decrease in mortality and the role of early aggressive hydration. Methods: A consecutive series of patients with acute pancreatitis from a single community hospital in1998 were compared to a consecutive series of patients with acute pancreatitis from the same institution in 2008. Results: Significantly more patients developed pancreatic necrosis; 26 (15%) of 173 patients in 1998 compared to 4 (4%) of 113 patients in 2008. The mean rate of hydration was significantly higher in 2008 compared with that in 1998 (P = 0.02). In 1998, hydration was provided at 184 mL/h during the first 6 hours and 188 mL/h during the first 12 hours compared with 284 mL/h during the first 6 hours and 221 mL/h during the first 12 hours in 2008. There was a significant decrease in mortality in 2008 compared with that in 1998 (3.5% vs 12%, P = 0.03). Conclusions: The decrease in mortality seen in patients with acute pancreatitis during the last decade may be related to the increased aggressive hydration preventing pancreatic necrosis. © 2011 Lippincott Williams & Wilkins, Inc.