Rising Prevalence of Opioid Use Disorder and Predictors for Opioid Use Disorder Among Hospitalized Patients With Chronic Pancreatitis : Pancreas

Secondary Logo

Journal Logo

Advanced Search
Original Articles

Rising Prevalence of Opioid Use Disorder and Predictors for Opioid Use Disorder Among Hospitalized Patients With Chronic Pancreatitis

Bilal, Mohammad MD∗; Chatila, Ahmed MD†; Siddiqui, Mohamed Tausif MD‡; Al-Hanayneh, Muhannad MD∗; Shah, Aun Raza MD§; Desai, Madhav MD, MPH∥; Wadhwa, Vaibhav MD; Parupudi, Sreeram MD, FACP, FACG∗; Casey, Brenna W. MD, FASGE#; Krishnan, Kumar MD#; Hernandez-Barco, Yasmin G. MD#

Author Information

From the ∗Division of Gastroenterology and Hepatology

†Department of Internal Medicine, The University of Texas Medical Branch, Galveston, TX

‡Department of Internal Medicine, New York Medical College, Valhalla, NY

§Department of Internal Medicine, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH

∥Division of Gastroenterology and Hepatology, University of Kansas Medical Center, Kansas City, KS

Division of Gastroenterology and Hepatology, Cleveland Clinic Florida, Weston, FL

#Division of Gastroenterology, Massachusetts General Hospital, Boston, MA.

Received for publication June 14, 2019; accepted September 19, 2019.

Address correspondence to: Yasmin G. Hernandez-Barco, MD, Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School 55 Fruit St, Blake 4, Boston, MA (e-mail: [email protected]).

The authors declare no conflict of interest.

Supplemental digital contents are available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s Web site (www.pancreasjournal.com).

Pancreas 48(10):p 1386-1392, 11/12 2019. | DOI: 10.1097/MPA.0000000000001430

Abstract

Objectives 

We aimed to evaluate the prevalence, impact, and predictors of opioid use disorder (OUD) in hospitalized chronic pancreatitis (CP) patients.

Methods 

A retrospective cohort study was performed using the National Inpatient Sample database from 2005 to 2014. Patients with a primary diagnosis of CP and OUD were included. The primary outcome was evaluating the prevalence and trend of OUD in patients hospitalized with CP. Secondary outcomes were to (1) assess the impact of OUD on health care resource utilization and (2) identify predictors of OUD in hospitalized CP patients.

Results 

A total of 176,857 CP patients were included, and OUD was present in 3.8% of patients. The prevalence of OUD in CP doubled between 2005 and 2014. Patients with CP who had OUD were found to have higher mean length of stay (adjusted mean difference, 1.2 days; P < 0.001) and hospitalization costs (adjusted mean difference, US $1936; P < 0.001). Independent predictors of OUD in CP patients were obesity, presence of depression, and increased severity of illness.

Conclusions 

Opioid use disorder–related diagnoses are increasing among CP patients and are associated with increased health care resource utilization. Our study identifies patients at high-risk for OUD whose pain should be carefully managed.

Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.

Full Text Access for Subscribers:

Not a Subscriber?

Buy
Request Permissions

You can read the full text of this article if you:

Access through Ovid