Biology, Pathobiology, and Disease

Second Edition

The classic textbook, “The Pancreas: Biology, Pathobiology and Diseases,” published by Raven Press in 1993 is now available in its entirety online on our journal’s website. This book summarizes the state of the art of our disciplines in biology, pathobiology and diseases of pancreas up to 1990. The articles that appear in the journal Pancreas, which started publishing in 1986, has provided most of the progress and advances in the field since then. The book is an excellent companion and provides continuity in the advances of pancreatology. We are grateful to our publisher, Lippincott Williams & Wilkins, for providing all the chapters of the book in open access and for providing additional references and historical perspective of our field.

Vay Liang W. (Bill) Go, M.D.

Contents

Table of Contents

Contributors…………………………………………………………………………………………... ix

Preface to the First Edition ………………………………………………………………………... xiii

Preface........................................................................................................................ xv

Acknowledgments………………………………………………………………………………….... xvii

Biology

1. Anatomy of the Pancreas…………………………………………………………………..… 1
   Dale E. Bockman
2. Fine Structure of the Human Exocrine Pancreas...................................................... 9
   Horst F. Kern
3. Differentiation and Development of the Pancreas in Animals………………………...…... 21
   Sherwood Githens
4. Prenatal and Postnatal Development of the Human Exocrine Pancreas…………........  57
   P. C. Lee and Emanuel Lebenthal
5. Replication and Regeneration of the Pancreas…………………………………………..… 75
   Hans-Peter Elsässer, Guido Adler, and Horst F. Kern
6. Transgenic Analysis of Pancreatic Function and Development……………….…..….….. 87
   Raymond J. MacDonald and Galvin H. Swift
7. Regulation of Pancreatic Gene Expression in Response to Hormones and
   Nutritional Substrates …………………………….....................…………………..…..… 103
   George A. Scheele
8. Cellular Compartmentation, Protein Processing, and Secretion in the
   Exocrine Pancreas………………………………………………………………………….... 121
   George A. Scheele and Horst F. Kern
9. Receptors for Secretagogues on Pancreatic Acinar Cells……………………………….. 151
   Jerry D. Gardner and Robert T. Jensen
10. Stimulus-Secretion Coupling in Pancreatic Acinar Cells…………………………….…... 167
    John A. Williams and David I. Yule
11. Electrophysiology of Acinar Cells…………………………………………………………... 191
    0. H. Petersen
12. Pancreatic Secretory Enzymes ………………………………………………………..…... 219
    Heinrich Rinderknecht
13. Lithostathine…………………………………………………………………………….........  253
    J. C. Dagorn
14. The Use of Two-Dimensional Gel Electrophoresis and High-Performance
    Liquid Chromatography for the Analysis of Pancreatic Juice…………………….....…… 265
    P.J. Padfield and George A. Scheele
15. Human Exocrine Pancreatic Enzyme Secretion....................................................... 275
    Eugene P. DiMagno and Peter Layer
16. Pancreatic Duct Cell Secretion: Control and Mechanisms of Transport…………...…… 301
    R. M. Case and B. E. Argent
17. Pancreatic Mucins ............................................................................................... 351
    Richard S. Metzgar, Michael A. Hollingsworth, and Bernard Kaufman
18. Extracellular Matrix as a Regulator of Epithelial Polarity, Cell Growth, and
    Tissue Pattern............……………………………………………………………………….. 369
    Donald E. Ingber
19. Neural Regulation of Pancreatic Exocrine Function……...…………...………..………... 381
    Jens Juul Holst
20. Hormonal Control of Pancreatic Exocrine Secretion…………………………………….... 403
    William Y Chey
21. Neurohormonal Control of Pancreatic Enzyme Secretion in Animals.......................... 425
    Manfred V. Singer
22. Interdependence of Nutrition and Exocrine Pancreatic Function................................. 449
    C. S. Pitchumoni and George A. Scheele
23. Luminal Digestion of Fats …………………………………………………….......…………. 475
    Bengt Borgström

Experimental Models

24. Experimental Acute Pancreatitis: Studies of the Early Events that Lead to Cell Injury................................................................................................................... 489
    Michael L. Steer and Ashok K. Saluja
25. Cerulein-Induced Pancreatitis................................................................................. 501
    Fred S. Gorelick, Guido Adler, and Horst F. Kern
26. Permeability Characteristics of the Main Pancreatic Duct in Cats: Models of
    Acute and Chronic Pancreatitis……………………………………...………………..…….. 527
    Howard A. Reber, Guido Adler, Nariman Karanjia, and Adam Widdison
27. Experimental Models of Exocrine Pancreatic Tumors …………..……………………….. 551
    Daniel S. Longnecker
28. Cell Lines of the Human and Rodent Exocrine Pancreas...…....………………………... 565
    Marsha L. Frazier and Daniel S. Longnecker

Pancreatitis

29.  Pancreatitis Definitions and Classification…………………………………………….…… 575
    Martin Sarner
30. Etiology and Pathophysiology of Acute Pancreatitis…………………………………….... 581
    Michael L. Steer
31. Medical Management of Acute Pancreatitis and Complications……………………....... 593
    Peter A. Banks
32. Diagnosis of Acute Pancreatitis………………………………………………….………….. 613
    Michael D. Levitt and John H. Eckfeldt
33. Acute Pancreatitis: Surgical Management……………………………………………........ 637
    John H. C. Ranson
34. Pancreatic Abscess………………………………………………...…........……………….. 649
    Edward L. Bradley III and Andrew L. Warshaw
35. Chronic Pancreatitis…………………………………………………………………...……… 665
    Eugene P. DiMagno, Peter Layer, and Jonathan E. Clain
36. The Surgical Treatment of Chronic Pancreatitis……………………………………………. 707
    Charles F. Frey
37. Diagnosis and Management of Pancreatic Pseudocysts, Pancreatic Ascites,
    And Pancreatic Fistulas……………………………………………………….......….……... 741
    William F. Maule and Howard A. Reber

Endocrine and Exocrine Pancreatic Relationships

38. Normal Function of the Endocrine Pancreas……………………………………………….. 751
    Murray Korc
39. The Microvasculature of the Pancreas, With Emphasis on That of the
    Islets of Langerhans: Anatomy and Functional Implications....................................... 759
    S. Bonner- Weir
40. The Enteroinsular Axis …………………………………………….................................. 769
    W Creutzfeldt and R. Ebert
41. The Insulin-Acinar Relationship............................................................................... 789
    John A. Williams and Ira D. Goldfine
42. Endocrine Changes in Pancreatic Insufficiency ...………………………………...………. 803
    Chung Owyang
43. Pancreas and Islet Transplantation…………………………………………….......……….. 815
    Alan C. Farney and David E. R. Sutherland

Pancreatic Neoplasms

44. Epidemiology and Etiology of Pancreatic Cancer………………………………………….. 837
    Leon Gordis and Ellen B. Gold
45. Fine Structure of Human Pancreatic Adenocarcinoma………………………...…...…….. 857
    Horst F. Kern and Hans-Peter Elsässer
46. Pathology of Nonendocrine Pancreatic Tumors......................................................... 871
    Gunter K1öppel
47. Exocrine Tumors of the Pancreas…………………………………………….......…..…..... 899
    Isaac Raijman and Bernard Levin
48. Surgical Management of Exocrine Pancreatic Cancer……………………..……………… 913
    Stanley W Ashley and Howard A. Reber
49. Gastrinoma........................................................................................................... 931
    Robert T. Jensen and Jerry D. Gardner
50. Insulinoma…………………………………………………………........……………………... 979
    Richard J. Comi, Phillip Gorden, and John L. Doppman
51. Miscellaneous Tumors of the Pancreas……………………………...……………………... 997
    P. J. Hammond, J. M. Polak, and S. R. Bloom
52. Surgery for Endocrine Tumors of the Pancreas………………….......…………………… 1009
    Jeffrey A. Norton, Gerard M. Doherty, and Douglas L. Fraker

Congenital and Hereditary Diseases

53. Congenital Abnormalities of the Exocrine Pancreas……………………………..........… 1029
    Ivor D. Hill and Emanuel Lebenthal
54. The Pancreas in Cystic Fibrosis………………………………………………...…..……… 1041
    Emanuel Lebenthal, Aaron Lerner, and David D. K. Rolston
55. Hereditary Diseases of the Pancreas…………………………………..........……………. 1083
    Aaron Lerner and Emanuel Lebenthal
56. Hereditary Pancreatitis…………………………………………….............……………….. 1095
    J. Armando Madrazo-de la Garza, Ivor D. Hill,and Emanuel Lebenthal

Imaging of the Pancreas

57. Imaging of the Pancreas……………..………………………………………………....…… 1103
    Robert L. MacCarty, Ellen M. Ward, J. William Charboneau,
    Patrick F. Sheedy II, and C. Daniel Johnson

Subject Index…………………………………………………………….............................…… 1137