Original ArticlesAssociation Between Family History and Risk of Pancreatic Cancer in Patients With BRCA1 and BRCA2 Pathogenic VariantsShah, Ishani MD∗; Silva-Santisteban, Andy MD∗; Germansky, Katharine A. MD∗; Kandasamy, Cinthana MD†; Mlabasati, Jack MD†; Huang, Dora C. MD†; Wadhwa, Vaibhav MD∗; Bilal, Mohammad MD∗; Sawhney, Mandeep S. MD, MS, FASGE∗ Author Information From the ∗Division of Gastroenterology, Department of Medicine †Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA. Received for publication February 28, 2022; accepted August 26, 2022. Address correspondence to: Mandeep S. Sawhney, MD, MS, FASGE, Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Rabb-Rose 101, Boston, MA 02215 (e-mail: [email protected]). M.S.S. worked on study concept and design. I.S., A.S.-S., C.K., J.M., and D.C.H. performed acquisition of data. I.S., A.S.-S., K.A.G., C.K., J.M., D.C.H., V.W., M.B., and M.S.S. did the analysis and interpretation of data. I.S., A.S.-S., and M.S.S. drafted the manuscript. I.S., A.S.-S., K.A.G., C.K., J.M., D.C.H., V.W., M.B., and M.S.S. provided critical revision of the manuscript for important intellectual content. M.S.S performed study supervision. The authors declare no conflict of interest. Pancreas: August 2022 - Volume 51 - Issue 7 - p 733-738 doi: 10.1097/MPA.0000000000002104 Buy Metrics Abstract Objectives Current guidelines limit pancreatic cancer screening to those BRCA1/2 patients who have a family history of pancreatic cancer. We aimed to assess the association between family history and risk of pancreatic neoplasms in BRCA1/2 patients. Methods We reviewed medical records of BRCA1/2 patients followed at our institution between 1995 and 2020. Family history was defined as those with a first-degree relative with pancreatic cancer. We compared the incidence and prevalence of pancreatic neoplasms between patients with and without family history of pancreatic cancer. Results We identified 56 BRCA1/2 patients with family history and 238 without family history of pancreatic cancer. No difference between these groups was noted in age, race, or sex. Mean follow-up interval for BRCA1/2 patients was 4.6 years (range, 0–19.7 years). There was no significant difference in prevalence (19.6% vs 12.6; P = 0.3) or incidence (29% vs 14.1%; P = 0.08) of branch-duct intraductal papillary mucinous neoplasm between the 2 groups. No association between family history and pancreatic cancer risk was noted. Only 1 of 10 BRCA1/2 patients with pancreatic cancer had a family history. Conclusions Our results do not support using family history to determine eligibility for pancreatic cancer screening. Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.