ReviewsTherapeutic Potentials of MicroRNAs for Curing Diabetes Through Pancreatic β-Cell Regeneration or ReplacementGhani, Muhammad Waseem MPhil∗; Li, Ye MPhil∗; Ghani, Hammad MBBS†; Birmani, Muhammad Waseem MPhil∗; Liu, Bin MPhil∗; Lang, Guan Cun MPhil∗; Zhang, Wenqi MPhil∗; Xiao, Mei PhD∗Author Information From the ∗Department of Animal Science and Medicine, College of Coastal Agricultural Sciences, Guangdong Ocean University, Zhanjiang, China †Nawaz Sharif Medical College, University of Gujrat, Punjab, Pakistan. Received for publication January 23, 2020; accepted June 25, 2020. M.W.G. and Y.L. contributed equally. Address correspondence to: Mei Xiao, PhD, Department of Animal Biotechnology, College of Coastal Agricultural Sciences, Gangdong Ocean University, Lab 412, Zhanjiang, China (e-mail: [email protected]). The authors declare no conflict of interest. Pancreas: October 2020 - Volume 49 - Issue 9 - p 1131-1140 doi: 10.1097/MPA.0000000000001655 Buy Metrics Abstract MicroRNAs are a type of noncoding RNAs that regulates the expression of target genes at posttranscriptional level. MicroRNAs play essential roles in regulating the expression of different genes involved in pancreatic development, β-cell mass maintenance, and β-cell function. Alteration in the level of miRNAs involved in β-cell function leads to the diabetes. Being an epidemic, diabetes threatens the life of millions of patients posing a pressing demand for its urgent resolve. However, the currently available therapies are not substantial to cure the diabetic epidemic. Thus, researchers are trying to find new ways to replenish the β-cell mass in patients with diabetes. One promising approach is the in vivo regeneration of β-cell mass or increasing the efficiency of β-cell function. Another clinical strategy is the transplantation of in vitro developed β-like cells. Owing to their role in pancreatic β-cell development, maintenance, functioning and their involvement in diabetes, overexpression or attenuation of different miRNAs can cause β-cell regeneration in vivo or can direct the differentiation of various kinds of stem/progenitor cells to β-like cells in vitro. Here, we will summarize different strategies used by researchers to investigate the therapeutic potentials of miRNAs, with focus on miR-375, for curing diabetes through β-cell regeneration or replacement. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.