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New-Onset Diabetes Mellitus After Chronic Pancreatitis Diagnosis

A Systematic Review and Meta-analysis

Zhu, Xiangyun MD*; Liu, Dechen PhD; Wei, Qiong PhD*; Lin, Hao PhD; Zhi, Mengmeng MD*; Chen, Yuling BD*; Qi, Liang BD*; Waldron, Richard T. PhD; Lugea, Aurelia PhD; Pandol, Stephen J. MD; Li, Ling MD*

doi: 10.1097/MPA.0000000000001359
Original Articles

Objectives The aim of this study was to assess the occurrence of new-onset diabetes mellitus (DM) after chronic pancreatitis (CP) diagnosis via systematic review and meta-analysis.

Methods A systematic review of literature and meta-analysis of relevant reports were performed. The primary outcome measures studied were newly diagnosed DM and DM treated with insulin. For the binary outcomes, pooled prevalence and 95% confidence interval (CI) were calculated.

Methods Fifteen studies involving 8970 patients were eligible. The incidence of new-onset DM after CP diagnosis was 30% (95% CI, 27%–33%). Among all patients, 17% (95% CI, 13%–22%) developed insulin-dependent new-onset DM. The prevalence of newly diagnosed DM after CP diagnosis increased from 15% within 36 months to 33% after 60 months. The proportion of alcoholic CP, sex, age, and body mass index had minimal effect on the studied outcomes.

Conclusions This systematic review identified a clinically relevant risk of new-onset DM after CP diagnosis. Therefore, patients should be informed of the risk of DM and monitored.

From the *Department of Endocrinology, School of Medicine, and

Department of Clinical Science and Research, Zhongda Hospital, Southeast University, Nanjing, China;

Division of Digestive and Liver Diseases, Cedars-Sinai Medical Center, Los Angeles, CA.

Received for publication October 24, 2018; accepted May 21, 2019.

Address correspondence to: Ling Li, MD, Department of Endocrinology, School of Medicine, Zhongda Hospital, Southeast University, No. 87, DingJiaQiao Rd, Nanjing 210009, China (e-mail:; and Stephen J. Pandol, MD, Division of Digestive and Liver Diseases, Cedars-Sinai Medical Center, 8700 Beverly Blvd., Los Angeles, CA (e-mail:

L.L. and S.J.P. contributed equally and are co-corresponding authors.

This study was funded by the National Natural Science Foundation of China (No. 81570739) and the Key Research and Development Program of Jiangsu Province (No. BE2018742).

The authors declare no conflict of interest.

Online date: July 2, 2019

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