ReviewsAnimal Models Challenges and Opportunities to Determine Optimal Experimental Models of Pancreatitis and Pancreatic CancerSaloman, Jami L. PhD*; Albers, Kathryn M. PhD*; Cruz-Monserrate, Zobeida PhD†; Davis, Brian M. PhD*; Edderkaoui, Mouad PhD‡; Eibl, Guido MD§; Epouhe, Ariel Y. BS*; Gedeon, Jeremy Y. BS*; Gorelick, Fred S. MD∥¶#; Grippo, Paul J. PhD**; Groblewski, Guy E. PhD††; Husain, Sohail Z. MD‡‡; Lai, Keane K.Y. MD§§∥∥¶¶; Pandol, Stephen J. MD‡; Uc, Aliye MD##; Wen, Li MD, PhD***; Whitcomb, David C. MD, PhD†††Author Information From the *Department of Neurobiology, Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA; †Division of Gastroenterology, Hepatology, and Nutrition, Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, OH; ‡Basic and Translational Pancreas Research, Cedars-Sinai Medical Center; §Department of Surgery, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA; ∥Department of Internal Medicine, Section of Digestive Diseases and ¶Department of Cell Biology, Yale University School of Medicine, New Haven, CT; #Veterans Affairs Connecticut Healthcare, West Haven, CT; **Department of Medicine, Division of Gastroenterology and Hepatology, UI Cancer Center, University of Illinois at Chicago, Chicago, IL; ††Department of Nutritional Sciences, University of Wisconsin, Madison, WI; ‡‡Department of Pediatrics, Stanford University, Palo Alto; §§Department of Pathology (National Medical Center), ∥∥Department of Molecular Medicine (Beckman Research Institute) and ¶¶Comprehensive Cancer Center, City of Hope, Duarte, CA; ##Stead Family Department of Pediatrics, Stead Family Children's Hospital, University of Iowa, Iowa City, IA; ***Department of Pediatrics, Children's Hospital of Pittsburgh, Pittsburgh, PA; and †††Department of Medicine, University of Pittsburgh, Pittsburgh, PA. Received for publication January 14, 2019; accepted April 25, 2019. Address correspondence to: Jami L. Saloman, PhD, Department of Neurobiology, Pittsburgh Center for Pain Research, University of Pittsburgh, 200 Lothrop St, BSWTR E1457, Pittsburgh, PA 15213 (e-mail: [email protected]). L.W. is currently with the Department of Gastroenterology, Shanghai General Hospital and Shanghai Key Laboratory of Pancreatic Disease, Institute of Pancreatic Disease, Shanghai Jiao Tong University School of Medicine, Shanghai, China. This study was supported by Hirshberg Foundation for Pancreatic Cancer Research and National Institutes of Health (NIH) K01DK120737 (J.L.S.); NIH R01CA177857 (B.M.D.); NIH K01AA019996 (M.E.); NIH P01CA163200 (G.E.); Veterans Administration Merit Award, NIH P01DK098108, and R01DK054021 (F.S.G.); NIH K08AA025112 (K.K.Y.L.); The National Pancreas Foundation and R01CA223204 (Z.C.M.); NIH U01DK108314 (S.J.P.); NIH U01DK108334 and R01DK118752 (A.U.); and NIH U01DK108306 (D.C.W.). A.U. is a member of the American Board of Pediatrics, Subboard of Pediatric Gastroenterology; associate editor of Pancreatology; and a consultant for Cystic Fibrosis Foundation. The rest of the authors declare no conflict of interest. Pancreas: July 2019 - Volume 48 - Issue 6 - p 759-779 doi: 10.1097/MPA.0000000000001335 Buy Metrics Abstract At the 2018 PancreasFest meeting, experts participating in basic research met to discuss the plethora of available animal models for studying exocrine pancreatic disease. In particular, the discussion focused on the challenges currently facing the field and potential solutions. That meeting culminated in this review, which describes the advantages and limitations of both common and infrequently used models of exocrine pancreatic disease, namely, pancreatitis and exocrine pancreatic cancer. The objective is to provide a comprehensive description of the available models but also to provide investigators with guidance in the application of these models to investigate both environmental and genetic contributions to exocrine pancreatic disease. The content covers both nongenic and genetically engineered models across multiple species (large and small). Recommendations for choosing the appropriate model as well as how to conduct and present results are provided. Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.