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Temporal Trends in Incidence and Outcomes of Acute Pancreatitis in Hospitalized Patients in the United States From 2002 to 2013

Brindise, Elizabeth, DO*; Elkhatib, Imad, MD; Kuruvilla, Aneesh, DO*; Silva, Rogelio, MD

doi: 10.1097/MPA.0000000000001228
Original Articles

Objectives We sought to examine temporal trends in incidence and outcomes of acute pancreatitis (AP) in hospitalized adult patients in the United States.

Methods Subjects were obtained from the Healthcare Cost and Utilization Project–Nationwide Inpatient Sample database using International Classification of Diseases, Ninth Revision, Clinical Modification codes for the years 2002–2013. Incidence of AP, all-cause mortality, cost, and duration of hospitalization were assessed.

Results We identified 4,791,802 cases of AP. A significant increase in the incidence of AP was observed from 9.48 cases per 1000 hospitalizations in 2002 to 12.19 per 1000 hospitalizations in 2013 (P < 0.001). In-hospital mortality decreased from 2.99 cases per 100 cases in 2002 to 2.04 cases per 100 cases in 2013 (P < 0.001). Mean length of stay decreased from 6.99 (standard deviation [SD], 9.37) days in 2002 to 5.74 (SD, 7.94) days in 2013 (P < 0.001). Cost of hospitalization increased from $27,827 (SD, $54,556) in 2002 to $49,772 (SD, $106,205) in 2013 (P < 0.001).

Conclusions Hospital admissions for AP in adults increased significantly in the United States from 2002 to 2013. In-hospital all-cause mortality and mean length of stay significantly decreased. In contrast, total cost of hospitalization rose.

From the *Department of Medicine, University of Illinois at Chicago/Advocate Christ Medical Center; and

Division of Gastroenterology, Department of Medicine, Advocate Christ Medical Center, Oak Lawn, IL.

Received for publication May 1, 2018; accepted November 13, 2018.

Address correspondence to: Rogelio Silva, MD, 4440 W 95th St, No. 131, Oak Lawn, IL 60453 (e-mail:

No financial support was received for this study.

The authors declare no conflict of interest.

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