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The Significant Value of Preoperative Prognostic Nutritional Index for Survival in Pancreatic Cancers: A Meta-analysis

Liu, Jiandong, MD*; Jiang, Shanshan, MD; Yang, Xinghua, MD; Li, Xiaoqiang, MD§; Wang, Ning, MD, PhD*

doi: 10.1097/MPA.0000000000001089

Nutritional status plays a significant value in the incidence of postoperative complications and survival rate after resection of cancers. The preoperative prognostic nutritional index (PNI) has recently been reported to be a simple, sensitive, and effective prognostic parameter in various cancers. We conducted a meta-analysis to explore the significant value of PNI in pancreatic cancers. We systematically searched electronic databases of PubMed, Embase, Cochrane Library, Web of Science, Wanfang Data, and Chinese National Knowledge Infrastructure. Then, relevant studies were selected to perform this meta-analysis. Eleven studies with a total of 2123 patients met the inclusion criteria of this meta-analysis. The pooled results revealed that a lower PNI was significantly correlated with poorer overall survival (hazard ratio, 1.57; 95% confidence interval, 1.40–1.77; P < 0.001). Preoperative PNI might be an efficient predictor of survival with pancreatic cancers.

From the *Department of General Surgery and

Laboratory of Gastrointestinal Onco-Pathology, The First Hospital of China Medical University, Shenyang;

Department of General Surgery, Changtu Center Hospital, Tieling; and

§Department of General Surgery, The First Hospital of Liangjiang New Area, Chongqing, China.

Received for publication October 21, 2017; accepted May 1, 2018.

Address correspondence to: Ning Wang, MD, PhD, Department of General Surgery, The First Hospital of China Medical University, 155 Nanjing North St, Heping District, Shenyang 110001, China (e-mail:

The authors declare no conflict of interest.

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