Case ReportCarcinoid Syndrome Complicating a Pancreatic Neuroendocrine Tumor A Case ReportGerson, James N. MD*; Witteles, Ronald M. MD†; Chang, Daniel T. MD‡; Beygui, Ramin E. MD, MSc§; Iagaru, Andrei H. MD∥; Kunz, Pamela L. MD¶ Author Information From the *Department of Hematology/Oncology, Fox Chase Cancer Center, Philadelphia, PA; †Division of Cardiovascular Medicine, Department of Medicine; ‡Department of Radiation Oncology, Stanford University School of Medicine, Stanford; §Department of Cardiovascular Surgery, UCSF Medical Center, San Francisco; ∥Department of Radiology (Nuclear Medicine); and ¶Department of Medicine (Division of Oncology), Stanford University School of Medicine, Stanford, CA. Received for publication February 13, 2017; accepted August 22, 2017. Address correspondence to: Pamela L. Kunz, MD, Department of Medicine (Division of Oncology), Stanford University School of Medicine, Stanford Cancer Center, 875 Blake Wilbur Drive, Stanford, CA 94305-5826 (e-mail: [email protected]). P.L.K. receives research funding to her institution from Novartis, Esanex, Advanced Accelerator Applications, Genentech, Lexicon, Merck, Oxigene, Dicerna, and Ipsen. She has served on advisory boards for Ipsen, Novartis, and Lexicon. The other authors declare no conflict of interest. Pancreas: 11/12 2017 - Volume 46 - Issue 10 - p 1381-1385 doi: 10.1097/MPA.0000000000000932 Buy Metrics Abstract Neuroendocrine tumors (NETs) comprise a heterogeneous group of neoplasms. These tumors can produce a wide variety of hormones that can lead to syndromes of hormone excess, such as carcinoid syndrome. We present the case of a 47-year-old man who presented with right upper quadrant abdominal pain and emesis. He was found to have metastatic pancreatic NET and was treated with systemic chemotherapy. He subsequently developed dyspnea on exertion and was found to have severe right-sided heart disease secondary to elevated levels of serum serotonin. He was successfully treated with surgical tricuspid and pulmonic valve replacement. True carcinoid syndrome with pancreatic NETs is rare, but, as a treatable complication of the disease, is an important entity for which oncologists should be familiar. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.