Susceptibility Locus for Lung Cancer at 15q25.1 Is Not Associated With Risk of Pancreatic Cancer : Pancreas

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Susceptibility Locus for Lung Cancer at 15q25.1 Is Not Associated With Risk of Pancreatic Cancer

Chen, Jinyun MD*; Wu, Xifeng MD, PhD*†; Pande, Mala PhD*; Amos, Christopher I. PhD*†; Killary, Ann M. PhD†‡; Sen, Subrata PhD§; Frazier, Marsha L. PhD*†

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Pancreas 40(6):p 872-875, August 2011. | DOI: 10.1097/MPA.0b013e318219dafe

Abstract

Objectives: 

Four genome-wide association (GWA) studies have found that variation in a region of strong linkage disequilibrium on the long arm of chromosome 15 (15q24-25.1) containing nicotinic acetylcholine receptor genes contributes to lung cancer risk. Because cigarette smoking is a major risk factor for developing both lung cancer and pancreatic cancer, we hypothesized that variation in this region may also modify individual susceptibility to pancreatic cancer.

Methods: 

We conducted a case-control study of 523 patients with pathologically confirmed pancreatic adenocarcinoma and 1046 age-, sex-, ethnicity-, and smoking behavior-matched cancer-free controls.

Results: 

We found that 2 risk single nucleotide polymorphisms reported in the lung cancer GWA studies-rs8034191: A>G and rs1051730: G>A, located in this 15q24-25.1 region-were not associated with risk of pancreatic cancer.

Conclusions: 

The results of our study suggest that the 2 single nucleotide polymorphisms at 15q25.1 do not modify pancreatic cancer risk.

© 2011 Lippincott Williams & Wilkins, Inc.

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