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Correction of Protein Metabolic Disorders by Composite Extract of Musa paradisiaca and Coccinia indica in Streptozotocin-Induced Diabetic Albino Rat: An Approach Through the Pancreas

Mallick, Chhanda MSc; De, Debasis MSc; Ghosh, Debidas MSc, PhD

doi: 10.1097/MPA.0b013e318192ebdf
Original Articles

Objective: The study focused on the ability of the extracts of Musa paradisiaca and Coccinia indica on protein metabolic disorders in streptozotocin (STZ)-induced diabetes.

Methods: Wistar strain rats were divided into 6 groups as control, control + composite extract treated, STZ-induced diabetes, diabetic + composite extract treated, composite extract-pretreated diabetes, and composite extract-pretreated diabetes + composite extract treated. Protein metabolic status was assessed by serum levels of urea, uric acid, albumin, and creatinine along with urine urea and albumin levels. Diabetic therapeutic ability was assessed by blood glucose, glycated hemoglobin, and serum insulin levels. Histology of the pancreas, liver, and kidney was evaluated.

Results: Indices of protein metabolic disorders were deviated from control in STZ-induced diabetes, which were protected significantly after the treatment of composite extract of M. paradisiaca and C. indica. This protection was more prominent when the extract-pretreated animals were subjected to diabetes induction by STZ.

Conclusion: The composite extract has a protective therapeutic effect against diabetes through β-cell regeneration capacity.

Abbreviations: STZ - streptozotocin, FBG - fasting blood glucose, BW - body weight, ANOVA - analysis of variance

From the Department of Bio-Medical Laboratory Science and Management (U.G.C. Innovative Department), Vidyasagar University, Midnapore, West Bengal, India.

Received for publication October 3, 2007; accepted October 17, 2008.

Reprints: Debidas Ghosh, MSc, PhD, Reader & Head, Bio-Medical Laboratory Science and Management (U.G.C. Innovative Department), Vidyasagar University, Midnapore 721 102, West Bengal, India (e-mail: debidas_ghosh@yahoo.co.in).

This study was supported by the University Grants Commission, project no. F7-11/2004, Government of India, and Indian Council of Medical Research, project no. 45/46/2006/BMS/TRM, Government of India, NewDelhi, for financial support.

© 2009 Lippincott Williams & Wilkins, Inc.