Correction of Protein Metabolic Disorders by Composite Extract of Musa paradisiaca and Coccinia indica in Streptozotocin-Induced Diabetic Albino Rat

An Approach Through the Pancreas

Abstract

Objective: 

The study focused on the ability of the extracts of Musa paradisiaca and Coccinia indica on protein metabolic disorders in streptozotocin (STZ)-induced diabetes.

Methods: 

Wistar strain rats were divided into 6 groups as control, control + composite extract treated, STZ-induced diabetes, diabetic + composite extract treated, composite extract-pretreated diabetes, and composite extract-pretreated diabetes + composite extract treated. Protein metabolic status was assessed by serum levels of urea, uric acid, albumin, and creatinine along with urine urea and albumin levels. Diabetic therapeutic ability was assessed by blood glucose, glycated hemoglobin, and serum insulin levels. Histology of the pancreas, liver, and kidney was evaluated.

Results: 

Indices of protein metabolic disorders were deviated from control in STZ-induced diabetes, which were protected significantly after the treatment of composite extract of M. paradisiaca and C. indica. This protection was more prominent when the extract-pretreated animals were subjected to diabetes induction by STZ.

Conclusion: 

The composite extract has a protective therapeutic effect against diabetes through β-cell regeneration capacity.

Abbreviations: STZ - streptozotocin, FBG - fasting blood glucose, BW - body weight, ANOVA - analysis of variance