PAIN Reports

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Radial nerve injury causes long-lasting forelimb sensory impairment and motor dysfunction in rats
Doctor shopping among chronic noncancer pain patients treated with opioids in the province of Quebec (Canada): incidence, risk factors, and association with the occurrence of opioid overdoses
Targeting the stress response in pediatric pain: current evidence for psychosocial intervention and avenues for future investigation
Brain gamma-aminobutyric acid, but not glutamine and glutamate levels are lower in older adults with chronic musculoskeletal pain: considerations by sex and brain location
A physiatrist's understanding and application of the current literature on chronic pelvic pain: a narrative review

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Current Issue Highlights

General Section

Best practices for virtual care to support youth with chronic pain and their families: a rapid systematic review to inform health care and policy during COVID-19 and beyond

Birnie, Kathryn A.; Killackey, Tieghan; Stinson, Jennifer; More

Birnie, Kathryn A.; Killackey, Tieghan; Stinson, Jennifer; Noel, Melanie; Lorenzetti, Diane L.; Marianayagam, Justina; Jordan, Isabel; Jordan, Evie; Neville, Alexandra; Pavlova, Maria; Campbell, Fiona; Lalloo, Chitra Less

PAIN Reports. 6(2):e935, August 2021.

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Evidence-informed guidance to better leverage, implement, and select virtual care platforms for pediatric chronic pain, and identified knowledge gaps are in need of additional research.

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Effects of joint and nerve mobilisation on neuroimmune responses in animals and humans with neuromusculoskeletal conditions: a systematic review and meta-analysis

Lutke Schipholt, Ivo J.; Coppieters, Michel W.; Meijer, Onno G.; More

Lutke Schipholt, Ivo J.; Coppieters, Michel W.; Meijer, Onno G.; Tompra, Nefeli; de Vries, Rob B. M.; Scholten-Peeters, Gwendolyne G. M. Less

PAIN Reports. 6(2):e927, August 2021.

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There is evidence that joint and nerve mobilisations compared with sham or no intervention positively influence various neuroimmune responses in animal and human neuromusculoskeletal conditions.

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SDC

Veteran engagement in opioid tapering research: a mission to optimize pain management

Colloca, Luana; Kisaalita, Nkaku R.; Bizien, Marcel; More

Colloca, Luana; Kisaalita, Nkaku R.; Bizien, Marcel; Medeiros, Michelle; Sandbrink, Friedhelm; Mullins, C. Daniel Less

PAIN Reports. 6(2):e932, August 2021.

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Dissociative and analgesic properties of ketamine are independent and unaltered by sevoflurane general anesthesia

Hahm, Eunice Y.; Chamadia, Shubham; Locascio, Joseph J.; More

Hahm, Eunice Y.; Chamadia, Shubham; Locascio, Joseph J.; Pedemonte, Juan C.; Gitlin, Jacob; Mekonnen, Jennifer; Ibala, Reine; Ethridge, Breanna R.; Colon, Katia M.; Qu, Jason; Akeju, Oluwaseun Less

PAIN Reports. 6(2):e936, August 2021.

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Ketamine-induced dissociation and analgesia are independent and robust to general anesthesia neural circuit alterations, suggesting that ketamine can be refined into a targeted pain therapeutic.

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Magnetoencephalography reveals increased slow-to-fast alpha power ratios in patients with chronic pain

Witjes, Bart; Baillet, Sylvain; Roy, Mathieu; More

Witjes, Bart; Baillet, Sylvain; Roy, Mathieu; Oostenveld, Robert; J.P.M. Huygen, Frank; C. de Vos, Cecile Less

PAIN Reports. 6(2):e928, August 2021.

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We report an increased slow-to-fast alpha power ratio of neurophysiological activity in chronic pain from known pain-processing areas, among others.

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Multidimensional health changes after a multimodal pain rehabilitation program: a registry-based study

Grimby-Ekman, Anna; Kim, Malin; Stankovic, Nenad; More

Grimby-Ekman, Anna; Kim, Malin; Stankovic, Nenad; Mannheimer, Clas Less

PAIN Reports. 6(2):e938, August 2021.

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A third of patients improved simultaneously in several domains, and a third improved in few or none. Pain intensity was the least likely outcome to improve.

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SDC

Dry needling has lasting analgesic effect in shoulder pain: a double-blind, sham-controlled trial

Pai, Marcus Yu Bin; Toma, Juliana Takiguti; Kaziyama, Helena Hideko Seguchi; More

Pai, Marcus Yu Bin; Toma, Juliana Takiguti; Kaziyama, Helena Hideko Seguchi; Listik, Clarice; Galhardoni, Ricardo; Yeng, Lin Tchia; Teixeira, Manoel Jacobsen; Ciampi de Andrade, Daniel Less

PAIN Reports. 6(2):e939, August 2021.

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Dry needling has analgesic effects in shoulder pain associated with myofascial pain syndrome. The analgesic effects last for up to 1 week.

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Psychology

Intrinsic attention to pain is associated with a pronociceptive phenotype

Adams, Greig; Harrison, Richard; Gandhi, Wiebke; More

Adams, Greig; Harrison, Richard; Gandhi, Wiebke; van Reekum, Carien M.; Salomons, Tim V. Less

PAIN Reports. 6(2):e934, August 2021.

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Capacity for modulation of incoming nociceptive signals is a determinant of our tendency to attend to pain.

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Trajectories of pain during pregnancy predict symptoms of postpartum depression

Mathur, Vani A.; Nyman, Tristin; Nanavaty, Namrata; More

Mathur, Vani A.; Nyman, Tristin; Nanavaty, Namrata; George, Nevita; Brooker, Rebecca J. Less

PAIN Reports. 6(2):e933, August 2021.

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Pain that increases from mid to late pregnancy deviates from normative patterns of change over time and is associated with elevated symptoms of postpartum depression.

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Basic Science

Mast cell stabilizer ketotifen fumarate reverses inflammatory but not neuropathic-induced mechanical pain in mice

Meloto, Carolina B.; Ingelmo, Pablo; Perez, Eduardo Vega; More

Meloto, Carolina B.; Ingelmo, Pablo; Perez, Eduardo Vega; Pitt, Rebecca; González Cárdenas, Víctor Hugo; Mohamed, Nada; Sotocinal, Susana G.; Bourassa, Valerie; Lima, Lucas Vasconcelos; Ribeiro-da-Silva, Alfredo; Mogil, Jeffrey S.; Diatchenko, Luda Less

PAIN Reports. 6(2):e902, August 2021.

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Our preclinical findings indicate that ketotifen fumarate's analgesic effects are MC-dependent, and the case series report presented supports its use for the treatment of chronic pain.

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Analgesic effect of central relaxin receptor activation on persistent inflammatory pain in mice: behavioral and neurochemical data

Abboud, Cynthia; Brochoire, Louison; Drouet, Adèle; More

Abboud, Cynthia; Brochoire, Louison; Drouet, Adèle; Hossain, M. Akhter; Hleihel, Walid; Gundlach, Andrew L.; Landry, Marc Less

PAIN Reports. 6(2):e937, August 2021.

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Relaxin peptide analogues produce strong but transient analgesia in inflammatory pain in mouse. Relaxin and its RXFP1 receptor represent a new peptidergic system that modulates pain processing in the forebrain areas.

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The methyl donor S-adenosyl methionine reverses the DNA methylation signature of chronic neuropathic pain in mouse frontal cortex

Topham, Lucas; Gregoire, Stephanie; Kang, HyungMo; More

Topham, Lucas; Gregoire, Stephanie; Kang, HyungMo; Salmon-Divon, Mali; Lax, Elad; Millecamps, Magali; Szyf, Moshe; Stone, Laura Less

PAIN Reports. 6(2):e944, August 2021.

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Chronic administration of S-adenosylmethionine reverses neuropathic pain–induced changes in DNA methylation in the mouse frontal cortex.

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Gucy2d selectively marks inhibitory dynorphin neurons in the spinal dorsal horn but is dispensable for pain and itch sensitivity

Serafin, Elizabeth K.; Burns, Robert; Yoo, Judy; More

Serafin, Elizabeth K.; Burns, Robert; Yoo, Judy; Baccei, Mark L. Less

PAIN Reports. 6(2):e947, August 2021.

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Gucy2d is expressed by spinal inhibitory neurons but is absent from brain and dorsal root ganglia. Gucy2d knockout mice respond normally to mechanical, heat, cold, and itch stimuli.

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Acute and Perioperative

A rat model to investigate quality of recovery after abdominal surgery

Cata, Juan P.; Patiño, Miguel; Lacagnina, Michael J.; More

Cata, Juan P.; Patiño, Miguel; Lacagnina, Michael J.; Li, Jiahe; Gorur, Aysegul; Agudelo-Jimenez, Ruben; Wei, Bo; Hagberg, Carin A.; Dougherty, Patrick M.; Shureiqi, Imad; Yang, Peiying; Grace, Peter M. Less

PAIN Reports. 6(2):e943, August 2021.

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Quantification of recovery after surgery can objectively perform in rats. Aspirin and eicosapentaenoic acid can modulate inflammation and enhance recovery after surgery.

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Neuropathic

C-tactile touch perception in patients with chronic pain disorders

Gossrau, Gudrun; Klimova, Anna; Lapp, Hanna Sophie; More

Gossrau, Gudrun; Klimova, Anna; Lapp, Hanna Sophie; Frost, Marie; Peschel, Elisabeth; Weidner, Kerstin; Koch, Thea; Sabatowski, Rainer; Croy, Ilona Less

PAIN Reports. 6(2):e941, August 2021.

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C-tactile stimulation in patients with chronic pain results in reduced pleasantness perception. Results suggest impaired C-tactile function with functional loss of pleasant touch perception in patients with postherpetic neuralgia.

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Analgesic effect of perineural local anesthetics, steroids, and conventional medical management for trauma and compression-related peripheral neuropathic pain: a retrospective cohort study

Bhatia, Anuj; Bril, Vera; Brull, Richard T.; More

Bhatia, Anuj; Bril, Vera; Brull, Richard T.; Perruccio, Anthony V.; Wijeysundera, Duminda N.; Lau, Johnny; Gandhi, Rajiv; Mahomed, Nizar; Davis, Aileen M. Less

PAIN Reports. 6(2):e945, August 2021.

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Perineural local anesthetic and steroid injections do not confer an analgesic benefit for trauma- or compression-related peripheral neuropathic pain. A higher degree of catastrophizing reduces the analgesic benefit with treatments for neuropathic pain.

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Table of Contents Sections

General Section
Psychology
Basic Science
Acute and Perioperative
Neuropathic

Latest Articles

2021 Global Year About Back Pain

Welcome to the 2021 Global Year About Back Pain! This year's theme focuses on helping clinicians, scientists, those living with pain, and the public understand the nature of back pain and the utility of available treatment modalities.

Articles published in PAIN related to this year's theme are marked with the Global Year logo and added to an article collection.

From IASP Press

Pain in Dementia

Stefan Lautenbacher, Stephen J. Gibson BBSc(Hon), PhD, MAPsS

With the help of Pain in Dementia, you can learn new ways to give dementia patients a better quality of life through identifying the source of their pain and recommending the most effective treatment options

Pain 2016 Refresher Courses: 16th World Congress on Pain

Claudia L Sommer MD, Steven P Cohen , Michaela Kress , Mark S Wallace

Presented at the 16th World Congress on Pain in Yokohama, Japan, in September 2016, these papers represent the thinking of the world's top pain scientists and clinicians

Pain in the Joints

Serge Perrot and Lars Arendt-Nielsen

A comprehensive overview of joint pain, including its assessment, mechanisms, and treatment options

Journal Info

August 2021, Vol. 6, Issue 2

Editor-in-Chief:
David Yarnitsky, MD

ISSN: 2471-2531

Frequency: publishing 4 issues in 2021

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