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Active metabolites of dipyrone induce a redox-dependent activation of the ion channels TRPA1 and TRPV1
The contribution of patients' pre-surgery perceptions of surgeon attributes to the experience of trust and pain during third...
Anatomic selectivity in overlap of chronic facial and bodily pain
Placebo and nocebo effects and operant pain-related avoidance learning
A rare complication of knee hematoma after genicular nerve radiofrequency ablation

Current Issue Highlights

Review

Cannabinoids, cannabis, and cannabis-based medicine for pain management a protocol for an overview of systematic reviews and a systematic review of randomised controlled trials

Fisher, Emma; Eccleston, Christopher; Degenhardt, Louisa; More

PAIN Reports. 4(3):e741, May/June 2019.

Open
SDC

Pharmacology

Risks of harm with cannabinoids, cannabis, and cannabis-based medicine for pain management relevant to patients receiving pain treatment protocol for an overview of systematic reviews

Gilron, Ian; Blyth, Fiona M.; Degenhardt, Louisa; More

PAIN Reports. 4(3):e742, May/June 2019.

Open
SDC

Active metabolites of dipyrone induce a redox-dependent activation of the ion channels TRPA1 and TRPV1

Schenk, Stefan Alexander; Dick, Felicia; Herzog, Christine; More

PAIN Reports. 4(3):e720, May/June 2019.

Open

Journal Club

Chronic pain breaking free from stickiness

Firouzian, Shahrzad; Osborne, Natalie R.

PAIN Reports. 4(3):e746, May/June 2019.

Open

General Section

Anatomical selectivity in overlap of chronic facial and bodily pain

Slade, Gary D.; Rosen, Jonathan D.; Ohrbach, Richard; More

PAIN Reports. 4(3):e729, May/June 2019.

Open
SDC

Does bedtime matter among patients with chronic pain? A longitudinal comparison study

McHugh, R. Kathryn; Edwards, Robert R.; Ross, Edgar L.; More

PAIN Reports. 4(3):e747, May/June 2019.

Open

Basic Science

Skilled reaching deterioration contralateral to cervical hemicontusion in rats is reversed by pregabalin treatment conditional upon its early administration

Erskine, Erin L.K.S.; Smaila, Brittney D.; Plunet, Ward; More

PAIN Reports. 4(3):e749, May/June 2019.

Open

Spinal microglia contribute to cancer-induced pain through system x_C⁻-mediated glutamate release

Miladinovic, Tanya; Singh, Gurmit

PAIN Reports. 4(3):e738, May/June 2019.

Open

Does toe clipping for genotyping interfere with later-in-life nociception in mice?

Frezel, Noémie; Kratzer, Gilles; Verzar, Philipp; More

PAIN Reports. 4(3):e740, May/June 2019.

Open

Musculoskeletal

Effect of sustained experimental muscle pain on joint position sense

Summers, Simon J.; Schabrun, Siobhan M.; Hirata, Rogerio P.; More

PAIN Reports. 4(3):e737, May/June 2019.

Open

A rare complication of knee hematoma after genicular nerve radiofrequency ablation

Strand, Natalie; Jorge, Paolo; Freeman, John; More

PAIN Reports. 4(3):e736, May/June 2019.

Open

Are painDETECT scores in musculoskeletal disorders associated with duration of daily pain and time elapsed since current pain onset?

Berthelot, Jean-Marie; Biha, Noura; Darrieutort-Laffite, Christelle; More

PAIN Reports. 4(3):e739, May/June 2019.

Open

Acute and Perioperative

Resting blood pressure modulates chest pain intensity in patients with acute myocardial infarction

Granot, Michal; Dagul, Pnina; Aronson, Doron

PAIN Reports. 4(3):e714, May/June 2019.

Open

Pain Around the World

Latin American Pain Federation position paper on appropriate opioid use in pain management

Garcia, João Batista Santos; Lopez, Maria Patricia Gomez; Barros, Guilherme Antonio Moreira; More

PAIN Reports. 4(3):e730, May/June 2019.

Open

Meeting Proceedings

Proceedings of Pain Science in Motion Colloquium—3rd edition. May 31st—June 2nd, University of Genoa-Campus of Savona, ItalyGiving insight in pain research of tomorrow!

van Wilgen, C. Paul; Testa, Marco

PAIN Reports. 4(3):e753, May/June 2019.

Open

Correspondence

Letter to the Editor Ketamine for pain management let's not neglect practical concerns

Cohen, Steven P.; Schwenk, Eric S.; Viscusi, Eugene R.; More

PAIN Reports. 4(3):e728, May/June 2019.

Open

Response to Cohen et al

Bell, Rae F.; Kalso, Eija A.

PAIN Reports. 4(3):e731, May/June 2019.

Open

Letter to the Editor Reduced intraepidermal nerve fiber density after a sustained increase in insular glutamate a proof-of-concept study examining the pathogenesis of small fiber pathology in fibromyalgia

Caro, Xavier J.; Winter, Earl F.

PAIN Reports. 4(3):e733, May/June 2019.

Open

Response to Caro and Winter

Harte, Steven E.; Clauw, Daniel J.; Feldman, Eva L.; More

PAIN Reports. 4(3):e734, May/June 2019.

Open

Placebo and Pain Research

From Bench-to-Bedside and Beyond

How do placebo effects and patient-clinician relationships influence behaviors and clinical outcomes?

Colloca, Luana

PAIN Reports. 4(3):e758, May/June 2019.

Open

Placebo analgesia effects across central nervous system diseases what do we know and where do we need to go?

Matthiesen, Susan Tomczak; Lunde, Sigrid Juhl; Wohlert Kjær, Sophie; More

PAIN Reports. 4(3):e717, May/June 2019.

Open

The impact of contextual factors on nursing outcomes and the role of placebo/nocebo effects a discussion paper

Palese, Alvisa; Rossettini, Giacomo; Colloca, Luana; More

PAIN Reports. 4(3):e716, May/June 2019.

Open

Magnitude, response, and psychological determinants of placebo effects in chronic low-back pain a randomised, double-blinded, controlled trial

Finniss, Damien; Nicholas, Michael; Brooker, Charles; More

PAIN Reports. 4(3):e744, May/June 2019.

Open

Placebo and nocebo effects and operant pain-related avoidance learning

Janssens, Thomas; Meulders, Ann; Cuyvers, Bien; More

PAIN Reports. 4(3):e748, May/June 2019.

Open
SDC

The contribution of patients' presurgery perceptions of surgeon attributes to the experience of trust and pain during third molar surgery

Ashton-James, Claire E.; Forouzanfar, Tymour; Costa, Daniel

PAIN Reports. 4(3):e754, May/June 2019.

Open

From Bench-to-Bedside and Beyond: Research Paper

A test of psychological and electrodermal changes immediately after the delivery of 3 analgesic treatment messages

Geers, Andrew L.; Fowler, Stephanie L.; Helfer, Suzanne G.; More

PAIN Reports. 4(3):e693, May/June 2019.

Open

Shaping placebo analgesic responses on the Internet a randomized experimental trial

Pontén, Moa; Ljótsson, Brjánn; Jensen, Karin

PAIN Reports. 4(3):e698, May/June 2019.

Open

From Bench-to-Bedside and Beyond: Review

How to prevent, minimize, or extinguish nocebo effects in pain a narrative review on mechanisms, predictors, and interventions

Manaï, Meriem; van Middendorp, Henriët; Veldhuijzen, Dieuwke S.; More

PAIN Reports. 4(3):e699, May/June 2019.

Open

ACTTION Special Issue on Clinical Trials of Pain Treatments

The ACTTION Guide to Clinical Trials of Pain Treatments standing on the shoulders of giants

Dworkin, Robert H.; Kerns, Robert D.; McDermott, Michael P.; More

PAIN Reports. 4(3):e757, May/June 2019.

Open

Ethical considerations in the design, execution, and analysis of clinical trials of chronic pain treatments

Rowbotham, Michael C.; McDermott, Michael P.

PAIN Reports. 4(3):e646, May/June 2019.

Open

Designing and conducting proof-of-concept chronic pain analgesic clinical trials

Campbell, Claudia M.; Gilron, Ian; Doshi, Tina; More

PAIN Reports. 4(3):e697, May/June 2019.

Open

Considerations of trial design and conduct in behavioral interventions for the management of chronic pain in adults

Edmond, Sara N.; Turk, Dennis C.; Williams, David A.; More

PAIN Reports. 4(3):e655, May/June 2019.

Open

Unique aspects of clinical trials of invasive therapies for chronic pain

Cohen, Steven P.; Wallace, Mark; Rauck, Richard L.; More

PAIN Reports. 4(3):e687, May/June 2019.

Open

Special considerations in conducting clinical trials of chronic pain management interventions in children and adolescents and their families

Palermo, Tonya M.; Kashikar-Zuck, Susmita; Friedrichsdorf, Stefan J.; More

PAIN Reports. 4(3):e649, May/June 2019.

Open

Current methods and challenges for acute pain clinical trials

Gilron, Ian; Carr, Daniel B.; Desjardins, Paul J.; More

PAIN Reports. 4(3):e647, May/June 2019.

Open

Opportunities and challenges for junior investigators conducting pain clinical trials

Adams, Meredith C.B.; Bicket, Mark C.; Murphy, Jamie D.; More

PAIN Reports. 4(3):e639, May/June 2019.

Open

Checklist for the preparation and review of pain clinical trial publications a pain-specific supplement to CONSORT

Gewandter, Jennifer S.; Eisenach, James C.; Gross, Robert A.; More

PAIN Reports. 4(3):e621, May/June 2019.

Open

2019 Global Year Against Pain in the Most Vulnerable

IASP Global Year 2019 Logo_4.jpg The 2019 Global Year Against Pain in the Most Vulnerable is underway. This year-long initiative offers resoruces for pain researchers and clinicians while focusing on the following vulnerable populations:

Pain in older persons (including pain in dementia)
Pain in infants and young children
Pain in individuals with cognitive impairments (non dementia-related) or psychiatric disorders
Pain in survivors of torture

Articles published in PAIN related to pain education are marked with the Global Year logo and added to an article collection.

From IASP Press

Pain in Dementia

Stefan Lautenbacher, Stephen J. Gibson BBSc(Hon), PhD, MAPsS

With the help of Pain in Dementia, you can learn new ways to give dementia patients a better quality of life through identifying the source of their pain and recommending the most effective treatment options

Pain 2016 Refresher Courses: 16th World Congress on Pain

Claudia L Sommer MD, Steven P Cohen , Michaela Kress , Mark S Wallace

Presented at the 16th World Congress on Pain in Yokohama, Japan, in September 2016, these papers represent the thinking of the world's top pain scientists and clinicians

Pain in the Joints

Serge Perrot and Lars Arendt-Nielsen

A comprehensive overview of joint pain, including its assessment, mechanisms, and treatment options