Nitroxidative stress in pain and opioid-induced adverse effects: therapeutic opportunities Squillace, Silvia; Salvemini, Daniela Squillace, Silvia; Salvemini, Daniela Less PAIN. 163(2):205-213, February 2022. Favorites PDF Get Content & Permissions Buy
Effects of booster sessions on self-management interventions for chronic musculoskeletal pain: a systematic review and meta-analysis of randomised controlled trials Buzasi, Eva; Kurakata, Hiroshi; Gandhi, Akash; More Buzasi, Eva; Kurakata, Hiroshi; Gandhi, Akash; Birch, Helen L.; Zarnegar, Roxaneh; Best, Lawrence Less PAIN. 163(2):214-257, February 2022. Abstract Abstract Favorites PDF Get Content & Permissions Buy SDC
Effect of intraoperative methadone vs other opioids on postoperative outcomes: a meta-analysis of randomized controlled studies Cheriyan, Thomas; Gaber, Mohamed; Glenn, Taylor; More Cheriyan, Thomas; Gaber, Mohamed; Glenn, Taylor; Latremouille, John; Loy, Kayla L.; Cheriyan, Jerry; Dua, Anterpeet; Singh, Paramvir; Kumar, Vikas; Omran, Mohamed Ben Less PAIN. 163(2):e153-e164, February 2022. Abstract Abstract Favorites PDF Get Content & Permissions Buy
At my own pace, space, and place: a systematic review of qualitative studies of enablers and barriers to telehealth interventions for people with chronic pain Fernandes, LĂvia G.; Devan, Hemakumar; Fioratti, Iuri; More Fernandes, LĂvia G.; Devan, Hemakumar; Fioratti, Iuri; Kamper, Steven J.; Williams, Christopher M.; Saragiotto, Bruno T. Less PAIN. 163(2):e165-e181, February 2022. Abstract Abstract Favorites PDF Get Content & Permissions Buy SDC
Perceived discrimination, health, and well-being among adults with and without pain: a prospective study Scott, Whitney; Jackson, Sarah E.; Hackett, Ruth A. Scott, Whitney; Jackson, Sarah E.; Hackett, Ruth A. Less PAIN. 163(2):258-266, February 2022. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: Discrimination is more common in people with pain than those without pain. Discrimination predicted greater depressive symptoms and loneliness over 6 years in those with pain. Buy SDC
Pain, cannabis use, and physical and mental health indicators among veterans and nonveterans: results from the National Epidemiologic Survey on Alcohol and Related Conditions-III Enkema, Matthew C.; Hasin, Deborah S.; Browne, Kendall C.; More Enkema, Matthew C.; Hasin, Deborah S.; Browne, Kendall C.; Stohl, Malki; Shmulewitz, Dvora; Fink, David S.; Olfson, Mark; Martins, Silvia S.; Bohnert, Kipling M.; Sherman, Scott E.; Cerda, Magdalena; Wall, Melanie; Aharonovich, Efrat; Keyhani, Salomeh; Saxon, Andrew J. Less PAIN. 163(2):267-273, February 2022. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: Pain is related to cannabis use, and the prevalence of cannabis use disorder is greater among veterans who reside in states with medical cannabis laws and report recent pain. Buy SDC
The translocator protein gene is associated with endogenous pain modulation and the balance between glutamate and γ-aminobutyric acid in fibromyalgia and healthy subjects: a multimodal neuroimaging study Fanton, Silvia; Sandström, Angelica; Tour, Jeanette; More Fanton, Silvia; Sandström, Angelica; Tour, Jeanette; Kadetoff, Diana; Schalling, Martin; Jensen, Karin B.; Sitnikov, Rouslan; Ellerbrock, Isabel; Kosek, Eva Less PAIN. 163(2):274-286, February 2022. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Go to Full Text of this Article In Brief: In subjects with fibromyalgia and healthy subjects, the genetically inferred translocator protein high-affinity binding variant was associated with brain region-specific metabolic patterns and reduced top-down pain modulation. Go to Full Text of this Article Open SDC
Longitudinal, bidirectional relationships of insomnia symptoms and musculoskeletal pain across adolescence: the mediating role of mood Arnison, Tor; Schrooten, Martien G.S.; Hesser, Hugo; More Arnison, Tor; Schrooten, Martien G.S.; Hesser, Hugo; Jansson-Fröjmark, Markus; Persson, Jonas Less PAIN. 163(2):287-298, February 2022. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: There is a bidirectional relationship between insomnia symptoms and pain in adolescents, and depressed and anxious mood mediate the effect of insomnia symptoms on pain. Buy SDC
Inhibition of transient receptor potential vanilloid 1 and transient receptor potential ankyrin 1 by mosquito and mouse saliva Derouiche, Sandra; Li, Tianbang; Sakai, Yuya; More Derouiche, Sandra; Li, Tianbang; Sakai, Yuya; Uta, Daisuke; Aoyagi, Seiji; Tominaga, Makoto Less PAIN. 163(2):299-307, February 2022. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Go to Full Text of this Article In Brief: We showed that mosquito and mouse saliva components, including the endopeptidase sialorphin, have antinociceptive properties through their action on transient receptor potential vanilloid 1 and transient receptor potential ankyrin 1 ion channels. Go to Full Text of this Article Open
Development of a bedside tool-kit for assessing sensitization in patients with chronic osteoarthritis knee pain or chronic knee pain after total knee replacement Sachau, Juliane; Otto, Jan C.; Kirchhofer, Viktoria; More Sachau, Juliane; Otto, Jan C.; Kirchhofer, Viktoria; Larsen, Jesper B.; Kennes, Lieven N.; HĂ¼llemann, Philipp; Arendt-Nielsen, Lars; Baron, Ralf Less PAIN. 163(2):308-318, February 2022. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Go to Full Text of this Article In Brief: An easy to use bedside test was developed to detect sensitization mechanisms in chronic painful knee osteoarthritis or chronic pain after total knee replacement. Go to Full Text of this Article Free SDC
Association between attentional bias to experimentally induced pain and to pain-related words in healthy individuals: the moderating role of interpretation bias Broadbent, Philippa; Schoth, Daniel E.; Liossi, Christina Broadbent, Philippa; Schoth, Daniel E.; Liossi, Christina Less PAIN. 163(2):319-333, February 2022. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: Among healthy participants, the association between attentional bias to pain words and attentional bias to the pain location was significantly moderated by interpretation bias. Buy SDC
Distinct synaptic mechanisms underlying the analgesic effects of γ-aminobutyric acid transporter subtypes 1 and 3 inhibitors in the spinal dorsal horn Oyama, Misa; Watanabe, Shun; Iwai, Takashi; More Oyama, Misa; Watanabe, Shun; Iwai, Takashi; Tanabe, Mitsuo Less PAIN. 163(2):334-349, February 2022. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Go to Full Text of this Article In Brief: Activation of GABAB receptors by endogenously increased glycine and/or γ-aminobutyric acid plays a crucial role in reducing excitatory synaptic transmission from primary afferents, leading to pain relief. Go to Full Text of this Article Free
Immersive interactive virtual walking reduces neuropathic pain in spinal cord injury: findings from a preliminary investigation of feasibility and clinical efficacy Trost, Zina; Anam, Monima; Seward, Joshua; More Trost, Zina; Anam, Monima; Seward, Joshua; Shum, Corey; Rumble, Deanna; Sturgeon, John; Mark, Victor; Chen, Yuying; Mitchell, Lucie; Cowan, Rachel; Perera, Robert; Richardson, Elizabeth; Richards, Scott; Gustin, Sylvia Less PAIN. 163(2):350-361, February 2022. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: An interactive virtual reality walking intervention demonstrated significantly larger reductions in spinal cord injury–related neuropathic pain and pain-related interference than a noninteractive control condition. Buy
Processing of trigeminocervical nociceptive afferent input by neuronal circuity in the upper cervical lamina I Fernandes, Elisabete C.; Carlos-Ferreira, José; Luz, Liliana L.; More Fernandes, Elisabete C.; Carlos-Ferreira, José; Luz, Liliana L.; Kokai, Eva; Meszar, Zoltan; Szucs, Peter; Safronov, Boris V. Less PAIN. 163(2):362-375, February 2022. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: Trigeminocervical nociceptors converge on to the upper cervical lamina I projection and inhibitory neurons. Convergent inhibitory neurons can balance excitatory drive to projection neurons. Buy
Cognitive therapy, mindfulness-based stress reduction, and behavior therapy for the treatment of chronic pain: randomized controlled trial Burns, John W.; Jensen, Mark P.; Thorn, Beverly; More Burns, John W.; Jensen, Mark P.; Thorn, Beverly; Lillis, Teresa A.; Carmody, James; Newman, Andrea K.; Keefe, Francis Less PAIN. 163(2):376-389, February 2022. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: Cognitive therapy, mindfulness-based stress reduction, and behavior therapy produced similar levels of beneficial effects at approximately the same rates for people with chronic low back pain. Results suggest the possibility that the specific techniques included in these treatments may be less important for outcomes than people participating in any techniques rooted in these empirically supported psychosocial treatments for chronic pain. Buy
Changes to the activity and sensitivity of nerves innervating subchondral bone contribute to pain in late-stage osteoarthritis Morgan, Michael; Thai, Jenny; Nazemian, Vida; More Morgan, Michael; Thai, Jenny; Nazemian, Vida; Song, Richard; Ivanusic, Jason J. Less PAIN. 163(2):390-402, February 2022. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Go to Full Text of this Article In Brief: Electrophysiological recordings in a rat model of osteoarthritis reveal pain in late stages of osteoarthritis involves activation and sensitization of nerves that innervate subchondral bone. Go to Full Text of this Article Open SDC
Pain by mistake: investigating a link between error-related negativity and pain avoidance behavior Traxler, Juliane; von Leupoldt, Andreas; Vlaeyen, Johan W.S. Traxler, Juliane; von Leupoldt, Andreas; Vlaeyen, Johan W.S. Less PAIN. 163(2):e190-e201, February 2022. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: The error-related negativity, reflecting neural error processing, was not associated with pain-related avoidance behavior in predictable or unpredictable contexts, with the exception of early acquisition. Buy
A Buthus martensii Karsch scorpion sting targets Nav1.7 in mice and mimics a phenotype of human chronic pain Lu, Wuguang; Cheng, Xiaoyang; Chen, Jiao; More Lu, Wuguang; Cheng, Xiaoyang; Chen, Jiao; Wang, Mingyuan; Chen, Yonggen; Liu, Jinman; Sang, Ming; Zhao, Ningwei; Yan, Huaijiang; Cheng, Xiaolan; Zhou, Qian; Ye, Juan; Wang, Jin; Xu, Erjin; Tang, Zongxiang; Zhou, Xi; Rong, Mingqiang; Nilsen, Erik A.; Dib-Hajj, Sulayman D.; Waxman, Stephen G.; Yu, Ye; Cao, Peng Less PAIN. 163(2):e202-e214, February 2022. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: This study establishes Nav 1.7 as primarily responsible for Buthus martensii Karsch scorpion sting–evoked pain and sheds new insights into the development of Nav1.7-selective modulators. Buy SDC
The exploration–exploitation dilemma in pain: an experimental investigation Krypotos, Angelos-Miltiadis; Crombez, Geert; Alves, Maryna; More Krypotos, Angelos-Miltiadis; Crombez, Geert; Alves, Maryna; Claes, Nathalie; Vlaeyen, Johan W.S. Less PAIN. 163(2):e215-e233, February 2022. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: We demonstrate that avoidance in pain could be better understood by focusing on the exploration–exploitation dilemma using a novel laboratory task and computational modelling. Buy SDC
Central sensitization inventory in endometriosis Orr, Natasha L.; Wahl, Kate J.; Lisonek, Michelle; More Orr, Natasha L.; Wahl, Kate J.; Lisonek, Michelle; Joannou, Angela; Noga, Heather; Albert, Arianne; Bedaiwy, Mohamed A.; Williams, Christina; Allaire, Catherine; Yong, Paul J. Less PAIN. 163(2):e234-e245, February 2022. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: A Central Sensitization Inventory cutoff of 40 had good sensitivity and specificity for identifying ≥3 central sensitivity syndromes and other pelvic pain-related comorbidities in endometriosis. Buy SDC
A qualitative trajectory analysis of patients' experiences tapering opioids for chronic pain McNeilage, Amy G.; Avery, Nicholas S.; Holliday, Simon; More McNeilage, Amy G.; Avery, Nicholas S.; Holliday, Simon; Glare, Paul A.; Ashton-James, Claire E. Less PAIN. 163(2):e246-e260, February 2022. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: The experience of tapering prescription opioids for chronic pain is variable, both within and between individuals. Readiness to taper and social support may shape the trajectory of patients' tapering experience. Buy SDC
Clinical relevance of attentional biases in pediatric chronic pain: an eye-tracking study Soltani, Sabine; van Ryckeghem, Dimitri M.L.; Vervoort, Tine; More Soltani, Sabine; van Ryckeghem, Dimitri M.L.; Vervoort, Tine; Heathcote, Lauren C.; Yeates, Keith O.; Sears, Christopher; Noel, Melanie Less PAIN. 163(2):e261-e273, February 2022. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: Attentional bias was demonstrated in youth with and without chronic pain using eye-tracking. Attentional bias was not associated with key theorized antecedents or clinical outcomes. Buy
Pregabalin vs placebo to prevent chronic pain after whiplash injury in at-risk individuals: results of a feasibility study for a large randomised controlled trial Nikles, Jane; Keijzers, Gerben; Mitchell, Geoffrey; More Nikles, Jane; Keijzers, Gerben; Mitchell, Geoffrey; Farrell, Scott F.; Perez, Siegfried; Schug, Stephan; Ware, Robert S.; McLean, Samuel A.; Connelly, Luke B.; Sterling, Michele Less PAIN. 163(2):e274-e284, February 2022. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: A future definitive trial of pregabalin for acute WAD may be feasible with protocol modifications. Pregabalin may be more effective than placebo at 3 months for neck pain intensity. Results will inform the design and logistics of a definitive multisite trial. Buy SDC
Gender differences in activity-limiting pain trajectories over a 17-year period in the Mexican Health and Aging Study Milani, Sadaf Arefi; Howrey, Bret; Rodriguez, Martin A.; More Milani, Sadaf Arefi; Howrey, Bret; Rodriguez, Martin A.; Samper-Ternent, Rafael; Wong, Rebeca Less PAIN. 163(2):e285-e292, February 2022. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Go to Full Text of this Article In Brief: Older Mexicans had 2 trajectories of activity-limiting pain (low-stable and moderate-increasing) over 17 years. Compared with men, women were more likely to have moderate-increasing pain. Go to Full Text of this Article Open SDC
Global, regional, and national burden of migraine in 204 countries and territories, 1990 to 2019 Safiri, Saeid; Pourfathi, Hojjat; Eagan, Arielle; More Safiri, Saeid; Pourfathi, Hojjat; Eagan, Arielle; Mansournia, Mohammad Ali; Khodayari, Mohammad Taghi; Sullman, Mark J.M.; Kaufman, Jay; Collins, Gary; Dai, Haijiang; Bragazzi, Nicola Luigi; Kolahi, Ali-Asghar Less PAIN. 163(2):e293-e309, February 2022. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: Globally, there were 1 billion prevalent cases, 87.6 million incident cases, and 42.1 million YLDs because of migraine in 2019. Buy SDC
Classification of chronic pain for the International Classification of Diseases (ICD-11): results of the 2017 international World Health Organization field testing Barke, Antonia; Korwisi, Beatrice; Jakob, Robert; More Barke, Antonia; Korwisi, Beatrice; Jakob, Robert; Konstanjsek, Nenad; Rief, Winfried; Treede, Rolf-Detlef Less PAIN. 163(2):e310-e318, February 2022. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Go to Full Text of this Article In Brief: The official WHO field tests of the International Classification of Diseases 11 classification of chronic pain demonstrate an excellent diagnostic coding performance and clinical utility of the new classification. Go to Full Text of this Article Open SDC
The beneficial effect of positive treatment expectations on pharmacological migraine prophylaxis Schmidt, Katharina; Berding, Tobias; Kleine-Borgmann, Julian; More Schmidt, Katharina; Berding, Tobias; Kleine-Borgmann, Julian; Engler, Harald; Holle-Lee, Dagny; Gaul, Charly; Bingel, Ulrike Less PAIN. 163(2):e319-e327, February 2022. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: Positive expectations towards pharmacological preventive treatment revealed beneficial effects on its efficacy, especially in more severely affected patients, underscoring their relevance in the treatment context. Buy SDC
Prevalence of chronic pain among adults in the United States Yong, R. Jason; Mullins, Peter M.; Bhattacharyya, Neil Yong, R. Jason; Mullins, Peter M.; Bhattacharyya, Neil Less PAIN. 163(2):e328-e332, February 2022. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: Using the 2019 National Health Interview Survey, this study investigates chronic pain prevalence and functional impacts on U.S. adults. Buy
Chronic widespread pain in children and adolescents presenting in primary care: prevalence and associated risk factors Somayajula, Glenys G.; Campbell, Paul; Protheroe, Joanne; More Somayajula, Glenys G.; Campbell, Paul; Protheroe, Joanne; Lacey, Rosie J.; Dunn, Kate M. Less PAIN. 163(2):e333-e341, February 2022. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: A significant proportion of children or adolescents have chronic widespread pain status in primary care. Many risk factors are pain based, suggesting potential pain development pathways. Buy SDC
Alcohol, coffee consumption, and smoking in relation to migraine: a bidirectional Mendelian randomization study Yuan, Shuai; Daghlas, Iyas; Larsson, Susanna C. Yuan, Shuai; Daghlas, Iyas; Larsson, Susanna C. Less PAIN. 163(2):e342-e348, February 2022. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: The Mendelian randomization study suggests causal evidence in a protective role of moderate coffee consumption and a detrimental role of cigarette smoking in migraine. Buy SDC
Evaluation of the effect of analgesic treatment on signs of nociception-related behaviors during physiotherapy in patients with disorders of consciousness: a pilot crossover randomized controlled trial Bonin, Estelle A.C.; Binda Fossati, Mariachiara L.; Filippini, Maria M.; More Bonin, Estelle A.C.; Binda Fossati, Mariachiara L.; Filippini, Maria M.; Bornheim, Stephen; Lejeune, Nicolas; O'Brien, Anthony T.; Bodart, Olivier; Laureys, Steven; Thibaut, Aurore; Chatelle, Camille Less PAIN. 163(2):e349-e356, February 2022. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: Physiotherapy may be potentially painful for patients with disorders of consciousness so careful attention with appropriate assessment and treatment, both before and during mobilization, should become a priority in clinical settings. Buy SDC
Using wearable technology to detect prescription opioid self-administration Salgado GarcĂa, Francisco I.; Indic, Premananda; Stapp, Joshua; More Salgado GarcĂa, Francisco I.; Indic, Premananda; Stapp, Joshua; Chintha, Keerthi K.; He, Zhaomin; Brooks, Jeffrey H.; Carreiro, Stephanie; Derefinko, Karen J. Less PAIN. 163(2):e357-e367, February 2022. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: Results from machine learning indicated that opioid self-administration could be identified with reasonable accuracy, suggesting that wearable technology can be for prevention and treatment. Buy
Conditional knockout of CRMP2 in neurons, but not astrocytes, disrupts spinal nociceptive neurotransmission to control the initiation and maintenance of chronic neuropathic pain Boinon, Lisa; Yu, Jie; Madura, Cynthia L.; More Boinon, Lisa; Yu, Jie; Madura, Cynthia L.; Chefdeville, Aude; Feinstein, Douglas L.; Moutal, Aubin; Khanna, Rajesh Less PAIN. 163(2):e368-e381, February 2022. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Go to Full Text of this Article In Brief: Collapsin response mediator protein 2 is a key regulator of glutamatergic sensory neurotransmission that contributes to the initiation and maintenance of chronic neuropathic pain. Go to Full Text of this Article Free
Discrimination as one of the social plights facing people with pain Karos, Kai Karos, Kai Less PAIN. 163(2):e149-e150, February 2022. Favorites PDF Get Content & Permissions Buy
Individual differences in the focus: understanding variations in pain-related fear and avoidance behavior from the perspective of personality science Hilger, Kirsten; Hewig, Johannes Hilger, Kirsten; Hewig, Johannes Less PAIN. 163(2):e151-e152, February 2022. Favorites PDF Get Content & Permissions Buy
Framework for opioid stigma in cancer pain Bulls, Hailey W.; Chu, Edward; Goodin, Burel R.; More Bulls, Hailey W.; Chu, Edward; Goodin, Burel R.; Liebschutz, Jane M.; Wozniak, Antoinette; Schenker, Yael; Merlin, Jessica S. Less PAIN. 163(2):e182-e189, February 2022. Abstract Abstract Favorites PDF Get Content & Permissions Buy
Can we improve patient outcomes through using evidence-based opioid deprescribing guidelines to reduce opioid use? Langford, Aili V.; Schneider, Carl R.; Lin, Chung-Wei Christine; More Langford, Aili V.; Schneider, Carl R.; Lin, Chung-Wei Christine; Gnjidic, Danijela Less PAIN. 163(2):e382, February 2022. Favorites PDF Get Content & Permissions Buy
Functional significance of macrophage-derived exosomes in inflammation and pain: erratum Less PAIN. 163(2):e383-e384, February 2022. Favorites PDF Get Content & Permissions Free Erratum
Dorsal root ganglion myeloid zinc finger protein 1 contributes to neuropathic pain after peripheral nerve trauma: erratum Less PAIN. 163(2):e384, February 2022. Favorites PDF Get Content & Permissions Free Erratum
