April 2021 - Volume 162 - Issue 4 : PAIN

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April 2021 - Volume 162 - Issue 4
pp: 989-1277





Stratification of patients based on the Neuropathic Pain Symptom Inventory: development and validation of a new algorithm

Bouhassira, Didier; Branders, Samuel; Attal, Nadine; More

PAIN. 162(4):1038-1046, April 2021.

Large-scale functional ultrasound imaging of the spinal cord reveals in-depth spatiotemporal responses of spinal nociceptive circuits in both normal and inflammatory states

Claron, Julien; Hingot, Vincent; Rivals, Isabelle; More

PAIN. 162(4):1047-1059, April 2021.

Calcium imaging in population of dorsal root ganglion neurons unravels novel mechanisms of visceral pain sensitization and referred somatic hypersensitivity

Gao, Xinyan; Han, Shu; Huang, Qian; More

PAIN. 162(4):1068-1081, April 2021.

Ubiquitin-mediated receptor degradation contributes to development of tolerance to MrgC agonist–induced pain inhibition in neuropathic rats

Huang, Qian; Ford, Neil C.; Gao, Xinyan; More

PAIN. 162(4):1082-1094, April 2021.

Impact of a policy change restricting access to codeine on prescription opioid-related emergency department presentations: an interrupted time series analysis

Elphinston, Rachel A.; Connor, Jason P.; de Andrade, Dominique; More

PAIN. 162(4):1095-1103, April 2021.

Safety and efficacy of an equimolar mixture of oxygen and nitrous oxide: a randomized controlled trial in patients with peripheral neuropathic pain

Bouhassira, Didier; Perrot, Serge; Riant, Thibault; More

PAIN. 162(4):1104-1115, April 2021.

Optogenetic inhibition of the colon epithelium reduces hypersensitivity in a mouse model of inflammatory bowel disease

Najjar, Sarah A.; Ejoh, Lindsay L.; Loeza-Alcocer, Emanuel; More

PAIN. 162(4):1126-1134, April 2021.

Complex sociodemographic inequalities in consultations for low back pain: lessons from multilevel intersectional analysis

Kiadaliri, Ali; Merlo, Juan; Englund, Martin

PAIN. 162(4):1135-1143, April 2021.

Are you in pain if you say you are not? Accounts of pain in Somali–Canadian women with female genital cutting

Perovic, Mateja; Jacobson, Danielle; Glazer, Emily; More

PAIN. 162(4):1144-1152, April 2021.

Different forms of traumatic brain injuries cause different tactile hypersensitivity profiles

Wattiez, Anne-Sophie; Castonguay, William C.; Gaul, Olivia J.; More

PAIN. 162(4):1163-1175, April 2021.

Sex- and age-specific genetic analysis of chronic back pain

Freidin, Maxim B.; Tsepilov, Yakov A.; Stanaway, Ian B.; More

PAIN. 162(4):1176-1187, April 2021.

Sex differences in brain modular organization in chronic pain

Fauchon, Camille; Meunier, David; Rogachov, Anton; More

PAIN. 162(4):1188-1200, April 2021.

The Parkinson disease pain classification system: results from an international mechanism-based classification approach

Mylius, Veit; Perez Lloret, Santiago; Cury, Rubens G.; More

PAIN. 162(4):1201-1210, April 2021.

Somatosensory and psychological phenotypes associated with neuropathic pain in entrapment neuropathy

Matesanz, Luis; Hausheer, Andrea C; Baskozos, Georgios; More

PAIN. 162(4):1211-1220, April 2021.

Trauma-focused cognitive behavioural therapy and exercise for chronic whiplash with comorbid posttraumatic stress disorder: a randomised controlled trial

Andersen, Tonny Elmose; Ravn, Sophie Lykkegaard; Armfield, Nigel; More

PAIN. 162(4):1221-1232, April 2021.

Thalamic neuroinflammation as a reproducible and discriminating signature for chronic low back pain

Torrado-Carvajal, Angel; Toschi, Nicola; Albrecht, Daniel S.; More

PAIN. 162(4):1241-1249, April 2021.

Antinociceptive properties of an isoform-selective inhibitor of Nav1.7 derived from saxitoxin in mouse models of pain

Beckley, Jacob T.; Pajouhesh, Hassan; Luu, George; More

PAIN. 162(4):1250-1261, April 2021.

Differential impact of keratinocytes and fibroblasts on nociceptor degeneration and sensitization in small fiber neuropathy

Kreß, Luisa; Hofmann, Lukas; Klein, Thomas; More

PAIN. 162(4):1262-1272, April 2021.



Creator: Erin Morrissey & Marco Loggia
Duration: 4:57
We used magnetic resonance spectroscopy to measure alterations in brain metabolites in patients with chronic knee pain due to knee osteoarthritis. Changes in neurometabolites were observed before and after total knee replacement, and differences observed between KOA patients and controls. Findings suggest that central nervous system alterations, including the role of glial cell activation and neuroinflammation, contribute to the pathophysiology of knee osteoarthritis.
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