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January 2021 - Volume 162 - Issue 1
pp: 1-322



The predictive value of quantitative sensory testing: a systematic review on chronic postoperative pain and the analgesic effect of pharmacological therapies in patients with chronic pain

Petersen, Kristian Kjær; Vaegter, Henrik B.; Stubhaug, Audun; More

PAIN. 162(1):31-44, January 2021.


Early changes in brain network topology and activation of affective pathways predict persistent pain in the rat

Sperry, Megan M.; Granquist, Eric J.; Winkelstein, Beth A.

PAIN. 162(1):45-55, January 2021.

Differential sensory and clinical phenotypes of patients with chronic widespread and regional musculoskeletal pain

Finnern, Marina M.; Kleinböhl, Dieter; Flor, Herta; More

PAIN. 162(1):56-70, January 2021.

Aberrant reactive aldehyde detoxification by aldehyde dehydrogenase-2 influences endometriosis development and pain-associated behaviors

McAllister, Stacy L.; Sinharoy, Pritam; Vasu, Megana; More

PAIN. 162(1):71-83, January 2021.

Chemotherapy-induced peripheral neuropathy in a dish: dorsal root ganglion cells treated in vitro with paclitaxel show biochemical and physiological responses parallel to that seen in vivo

Li, Yan; Marri, Tejaswi; North, Robert Y.; More

PAIN. 162(1):84-96, January 2021.

Abnormal subgenual anterior cingulate circuitry is unique to women but not men with chronic pain

Osborne, Natalie R.; Cheng, Joshua C.; Rogachov, Anton; More

PAIN. 162(1):97-108, January 2021.

Machine learning suggests sleep as a core factor in chronic pain

Miettinen, Teemu; Mäntyselkä, Pekka; Hagelberg, Nora; More

PAIN. 162(1):109-123, January 2021.

Spinal caspase-6 regulates AMPA receptor trafficking and dendritic spine plasticity through netrin-1 in postoperative pain after orthopedic surgery for tibial fracture in mice

Cui, Wei; Li, Yize; Wang, Zhen; More

PAIN. 162(1):124-134, January 2021.

Nociceptor-localized cGMP-dependent protein kinase I is a critical generator for central sensitization and neuropathic pain

Wang, Fei; Ma, Sui-Bin; Tian, Zhi-Cheng; More

PAIN. 162(1):135-151, January 2021.

A longitudinal examination of the interpersonal fear avoidance model of pain: the role of intolerance of uncertainty

Neville, Alexandra; Kopala-Sibley, Daniel C.; Soltani, Sabine; More

PAIN. 162(1):152-160, January 2021.

Netrin-1 receptor DCC is required for the contralateral topography of lamina I anterolateral system neurons

Bourojeni, Farin B.; Zeilhofer, Hanns Ulrich; Kania, Artur

PAIN. 162(1):161-175, January 2021.

Intradural artery dilation during experimentally induced migraine attacks

Christensen, Casper E.; Younis, Samaira; Lindberg, Ulrich; More

PAIN. 162(1):176-183, January 2021.

Cold pain hypersensitivity predicts trajectories of pain and disability after low back surgery: a prospective cohort study

Müller, Monika; Bütikofer, Lukas; Andersen, Ole K.; More

PAIN. 162(1):184-194, January 2021.

Prevalence of chronic pain in opioid-maintained patients using the capture–recapture method: a nationwide population-based study

Delorme, Jessica; Bertin, Célian; Delage, Noémie; More

PAIN. 162(1):195-202, January 2021.

Single-nucleus characterization of adult mouse spinal dynorphin-lineage cells and identification of persistent transcriptional effects of neonatal hindpaw incision

Serafin, Elizabeth K.; Paranjpe, Aditi; Brewer, Chelsie L.; More

PAIN. 162(1):203-218, January 2021.

Assessing the validity of health administrative data compared to population health survey data for the measurement of low back pain

Wong, Jessica J.; Côté, Pierre; Tricco, Andrea C.; More

PAIN. 162(1):219-226, January 2021.

Pharmacological modulation of voltage-gated sodium (NaV) channels alters nociception arising from the female reproductive tract

Castro, Joel; Maddern, Jessica; Erickson, Andelain; More

PAIN. 162(1):227-242, January 2021.

SARS-CoV-2 spike protein co-opts VEGF-A/neuropilin-1 receptor signaling to induce analgesia

Moutal, Aubin; Martin, Laurent F.; Boinon, Lisa; More

PAIN. 162(1):243-252, January 2021.

Effect of combined pharmacological, behavioral, and physical interventions for procedural pain on salivary cortisol and neurobehavioral development in preterm infants: a randomized controlled trial

Gao, Haixia; Xu, Guihua; Li, Fang; More

PAIN. 162(1):253-262, January 2021.

Activation of the Notch signaling pathway in the anterior cingulate cortex is involved in the pathological process of neuropathic pain

Duan, Haifeng; Shen, Fengyan; Li, Li; More

PAIN. 162(1):263-274, January 2021.

Modality-specific facilitation of noninjurious sharp mechanical pain by topical capsaicin

Shabes, Polina; C. Rosenberger, Daniela; Henrich, Florian; More

PAIN. 162(1):275-286, January 2021.

An experimental investigation into the mediating role of pain-related fear in boosting nocebo hyperalgesia

Thomaidou, Mia Athina; Veldhuijzen, Dieuwke Swaantje; Meulders, Ann; More

PAIN. 162(1):287-299, January 2021.

GABA and glutamate in pediatric migraine

Bell, Tiffany; Stokoe, Mehak; Khaira, Akashroop; More

PAIN. 162(1):300-308, January 2021.

Opioid-induced constipation in patients with cancer: a “real-world,” multicentre, observational study of diagnostic criteria and clinical features

Davies, Andrew; Leach, Charlotte; Butler, Claire; More

PAIN. 162(1):309-318, January 2021.



Creator: Wenbin Wu, MD. Fourth Military Medical University
Duration: 8:38
Dr. Ceng Luo and Fei Wang unraveled a peripheral target, PKG-I localized in primary afferent nociceptors, which influences central sensitization by enhancing cortical plasticity in the ACC via regulation of BDNF function after nerve injury. Developing analgesic therapeutics against peripheral PKG-I may pave the new way for treatment of neuropathic pain with least side effects.
Creator: Emanuele M. Giusti, PhD
Duration: 4:39
This video presents a systematic review and meta-analysis which was undertook to assess the strength of the association between psychological predictors and chronic post-surgical pain. The results suggest that state anxiety is the psychological predictor with the highest effect size, followed by catastrophizing, depression and trait anxiety. Mental health, kinesiophobia and self-efficacy had small effect sizes and optimism was not significantly associated with chronic post-surgical pain. These results have implications for the identifications of patients at risk.
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