January 2021 - Volume 162 - Issue 1 : PAIN

Video Abstract of study titled Intradural Artery Dilation During Experimentally Induced Migraine Attacks. First author Casper Emil Christensen and last author Messoud Ashina describe the study background, findings and interpretation.

Play

Nociceptor-localized cGMP-dependent protein kinase I is a critical generator for central sensitization and neuropathic pain

Creator: Wenbin Wu, MD. Fourth Military Medical University

Duration: 8:38

PAIN January 2021, Volume 162, Issue 1;

Show Less

Dr. Ceng Luo and Fei Wang unraveled a peripheral target, PKG-I localized in primary afferent nociceptors, which influences central sensitization by enhancing cortical plasticity in the ACC via regulation of BDNF function after nerve injury. Developing analgesic therapeutics against peripheral PKG-I may pave the new way for treatment of neuropathic pain with least side effects.

Play

Aberrant reactive aldehyde detoxification by ALDH2 influences endometriosis development and pain-associated behaviors

Creator:

Duration: 5:25

PAIN January 2021, Volume 162, Issue 1;

Play

Early changes in brain network topology and activation of affective pathways predict persistent pain in the rat

Creator: Megan Sperry

Duration: 4:46

PAIN January 2021, Volume 162, Issue 1;

Play

Psychological and psychosocial predictors of chronic post-surgical pain: a systematic review and meta-analysis

Creator: Emanuele M. Giusti, PhD

Duration: 4:39

PAIN January 2021, Volume 162, Issue 1;

Show Less

This video presents a systematic review and meta-analysis which was undertook to assess the strength of the association between psychological predictors and chronic post-surgical pain. The results suggest that state anxiety is the psychological predictor with the highest effect size, followed by catastrophizing, depression and trait anxiety. Mental health, kinesiophobia and self-efficacy had small effect sizes and optimism was not significantly associated with chronic post-surgical pain. These results have implications for the identifications of patients at risk.

Play

Castro et al., Vaginal afferents PAIN 2020

Creator: Prof Stuart Brierley

Duration: 4:42

PAIN January 2021, Volume 162, Issue 1;

Play

Core outcome set for pediatric chronic pain clinical trials: results from a Delphi poll and consensus meeting

Creator: Tonya Palermo

Duration: 5:35

PAIN January 2021, Volume 162, Issue 1;

Show Less

This study presents a new Core Outcome Set for pediatric chronic pain interventions using an accepted framework and methodology that will advance care for children with chronic pain.

Play

Efficacy and safety of EMA401 in peripheral neuropathic pain: Results of two randomised, double-blind, phase 2 studies in patients with postherpetic neuralgia and painful diabetic neuropathy

Creator: Novartis Pharma AG, Basel, Switzerland

Duration: 4:23

PAIN January 2021, Volume 162, Issue 1;

Show Less

This is a combined report of two prematurely terminated phase 2b placebo controlled randomised double blind parallel group multicentre clinical trials of EMA401, an angiotensin II type 2 receptor antagonist, in peripheral neuropathic pain.

Play

January 2021 - Volume 162 - Issue 1 : PAIN

In Brief:

In Brief:

In Brief:

In Brief:

In Brief:

In Brief:

In Brief:

In Brief:

In Brief:

In Brief:

In Brief:

In Brief:

In Brief:

In Brief:

In Brief:

In Brief:

In Brief:

In Brief:

In Brief:

In Brief:

In Brief:

In Brief:

In Brief: